CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014158
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribonucleoprotein PTB-binding 1 
Protein Synonyms/Alias
 Protein raver-1 
Gene Name
 Raver1 
Gene Synonyms/Alias
 Raver1h 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
571GSKAFPMKPRLLSPIacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity). 
Sequence Annotation
 DOMAIN 59 130 RRM 1.
 DOMAIN 132 210 RRM 2.
 DOMAIN 221 299 RRM 3.
 REGION 307 401 Interaction with PTBP1 (By similarity).
 MOTIF 45 60 Nuclear localization signal (Potential).
 MOTIF 743 746 Nuclear localization signal (Potential).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 14 14 Phosphoserine (By similarity).
 MOD_RES 469 469 Phosphothreonine (By similarity).
 MOD_RES 480 480 Phosphoserine (By similarity).
 MOD_RES 576 576 Phosphoserine (By similarity).
 MOD_RES 626 626 Phosphoserine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 748 AA 
Protein Sequence
MAADVSVTHR PPLSPEAEAE AETPETVDRR TPEQELPPLD PEEIRKRLEH TERQFRNRRK 60
ILIRGLPGDV TNQEVHDLLS DYELKYCFVD KYKGTAFVTL LNGEQAEAAI NTFHQSRLRE 120
RELSVQLQPT DALLCVANLP PSLTQAQFEE LVRPFGSLER CFLVYSERTG HSKGYGFAEY 180
MKKDSAARAK SDLLGKPLGP RTLYVHWTDA GQLTPALLHS RCLCVDHLPP GFNDVDALRQ 240
ALSAVYTPTF CQLASGQDGQ LKGFAVLEYE TAEMAEAAQQ RADGLALGGS HLRVSFCAPG 300
PPGRSMLAAL IAAQATALNR GKGLLPEPNI LQLLNNLGPS ASLQLLLNPL LHGGASGKQG 360
LLGAPPAMPL LSGPALSTAL LQLALQSQNQ SQSQSQKKPG ILGDSPLGTL QAGAQPSNSL 420
LGELSAGGGL APELPPRRGK PQPLLPPLLG PSGGDREPMG LGPPASQLTP PPAPMGLRGS 480
SLRGLPKDSG PLPTPPGVSL LGEPPKDYRI PLNPYLNLHS LLPSSNLAGK ETRGWGGSGR 540
GRRPAEPPLP SPAVPGGGNA SNNGSKAFPM KPRLLSPIAS NRLPPEPGLP DSYSFDYPTD 600
VGPRRLFSHP RESNLGAHGP SRHKMSPPPS SFSEPRSGGG SGGPLSHFYS GSPTSYFTSG 660
LQAGLKQSHL NKAVGSSPMG SSEGLLGLGP GPNGHSHLLK TPLGGQKRSF SHLLPSPEPS 720
PEGSYVGQHS QGLGGHYADS YLKRKRIF 748 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS