UniProt Accession

 TBC23_HUMAN; Q9NUY8; Q8TCN8; Q8WUB7; Q96D90; Q9NV75 

Genbank Protein ID

 AK001750; AK001908; AC078783; AC093003; BC010221; BC020955; AL713684; AY740521 

Genbank Nucleotide ID

 BAA91881.1; BAA91973.1; AAH10221.1; AAH20955.1; CAD28488.1; AAW66944.1 

Protein Name

 TBC1 domain family member 23 

Protein Synonyms/Alias

 HCV non-structural protein 4A-transactivated protein 1 

Gene Name

 TBC1D23 

Gene Synonyms/Alias

 NS4ATP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
489	GMKSLVNKMTVALKT	ubiquitination	[1]
495	NKMTVALKTKSVNVR	ubiquitination	[2]
504	KSVNVREKVISFIEN	ubiquitination	[1, 2]
648	VVKITSKKKHPELIT	ubiquitination	[3]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048] 

Functional Description

  

Sequence Annotation

 DOMAIN 44 225 Rab-GAP TBC.
 DOMAIN 334 446 Rhodanese.
 MOD_RES 474 474 Phosphoserine.
 MOD_RES 507 507 Phosphoserine.
 MOD_RES 514 514 Phosphothreonine.  

Keyword

 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 699 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 

Interpro

 IPR000195; Rab-GTPase-TBC_dom.
 IPR001763; Rhodanese-like_dom. 

Pfam

 PF00566; RabGAP-TBC
 PF00581; Rhodanese 

SMART

 SM00164; TBC 

PROSITE

 PS50206; RHODANESE_3
 PS50086; TBC_RABGAP 

PRINTS