UniProt Accession

 AKA7A_MOUSE; O55074; G3X9Q5 

Genbank Protein ID

 AF047716; AC153549; AC153550; CH466540 

Genbank Nucleotide ID

 AAC40085.1; EDL04795.1 

Protein Name

 A-kinase anchor protein 7 isoform alpha 

Protein Synonyms/Alias

 AKAP-7 isoform alpha; A-kinase anchor protein 18; AKAP-18; A-kinase anchor protein 9 kDa; AKAP 9; Protein kinase A-anchoring protein 7 isoform alpha; PRKA7 isoform alpha 

Gene Name

 Akap7 

Gene Synonyms/Alias

 Akap18 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
55	YLEETQNKKQPGEGN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium (By similarity). 

Sequence Annotation

 REGION 2 11 Required for membrane localization (By
 REGION 29 42 RII-binding (By similarity).
 LIPID 2 2 N-myristoyl glycine.
 LIPID 5 5 S-palmitoyl cysteine.
 LIPID 6 6 S-palmitoyl cysteine.  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Lipoprotein; Membrane; Myristate; Palmitate; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 81 AA 

Protein Sequence

Gene Ontology

 GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0051018; F:protein kinase A binding; ISS:UniProtKB.
 GO:0019901; F:protein kinase binding; IDA:MGI.
 GO:0008104; P:protein localization; ISA:MGI.
 GO:0007178; P:transmembrane receptor protein serine/threonine kinase signaling pathway; ISA:MGI. 

Interpro

 IPR019511; Kinase-A_anchor_RI-RII-bd_dom. 

Pfam

 PF10470; AKAP7_RIRII_bdg 

SMART

  

PROSITE

  

PRINTS