UniProt Accession

 ZNF22_HUMAN; P17026; Q5T741; Q96FM4 

Genbank Protein ID

 S50223; AY137767; BT009806; AK291508; AL353801; CH471160; BC010642; BC041139; BC053687; M77172; X52346 

Genbank Nucleotide ID

 AAB24264.2; AAN15804.1; AAP88808.1; BAF84197.1; CAI13068.1; EAW86632.1; AAH10642.1; AAH41139.1; AAH53687.1; AAA36815.1; CAA36572.1 

Protein Name

 Zinc finger protein 22 

Protein Synonyms/Alias

 Zinc finger protein KOX15; Zinc finger protein Krox-26 

Gene Name

 ZNF22 

Gene Synonyms/Alias

 KOX15; KROX26 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
18	SRSSSQGKAYENKRK	acetylation	[1, 2]
32	KTGRQRQKWGMTIRF	ubiquitination	[3]
218	WKAGTGRKSVAGLR*	acetylation	[2]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity). 

Sequence Annotation

 ZN_FING 55 77 C2H2-type 1.
 ZN_FING 83 105 C2H2-type 2.
 ZN_FING 111 133 C2H2-type 3.
 ZN_FING 139 161 C2H2-type 4.
 ZN_FING 167 189 C2H2-type 5.  

Keyword

 Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 224 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0003677; F:DNA binding; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; TAS:ProtInc.
 GO:0042476; P:odontogenesis; NAS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF00096; zf-C2H2 

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS