CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034125
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein polybromo-1 
Protein Synonyms/Alias
  
Gene Name
 Pbrm1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
414PFFHLPSKKKYPDYYacetylation[1, 2]
591EGMMEDMKLMFRNARubiquitination[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Bromodomain; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1461 AA 
Protein Sequence
MGSKRRRATS PSSSVSGDFD DGHHSVPTPG PSRKRRRLSN LPTVDPIAVC HELYNTIRDY 60
KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK LKMEEYDDVN LLTADFQLLF 120
NNAKAYYKPD SPEYKAACKL WDLYLRTRNE FVQKGEADDE DDDEDGQDNQ GTLADGSSPG 180
YLKEILEQLL EAIVVATNPS GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG 240
SYKSIHAMAK DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMTKSSLRIR 300
TASNLAAARL TGPSHNKSSL GEERNPTSKY YRNKRAVQGG RLSAITMALQ YGSESEEDAA 360
LAAARYEEGE SEAESITSFM DVSNPFHQLY DTVRSCRNHQ GQLIAEPFFH LPSKKKYPDY 420
YQQIKMPISL QQIRTKLKNQ EYETLDHLEC DLNLMFENAK RYNVPNSAIY KRVLKLQQVM 480
QAKKKELARR DDIEDGDSMI SSATSDTGSA KRKSKKNIRK QRMKILFNVV LEAREPGSGR 540
RLCDLFMVKP SKKDYPDYYK IILEPMDLKI IEHNIRNDKY AGEEGMMEDM KLMFRNARHY 600
NEEGSQVYND AHILEKLLKD KRKELGPLPD DDDMASPKLK LSRKSGVSPK KSKYMTPMQQ 660
KLNEVYEAVK NYTDKRGRRL SAIFLRLPSR SELPDYYLTI KKPMDMEKIR SHMMANKYQD 720
IDSMVEDFVM MFNNACTYNE PESLIYKDAL VLHKVLLETR RDLEGDEDSH VPNVTLLIQE 780
LIHNLFVSVM SHQDDEGRCY SDSLAEIPAV DPNSPNKPPL TFDIIRKNVE SNRYRRLDLF 840
QEHMFEVLER ARRMNRTDSE IYEDAVELQQ FFIRIRDELC KNGEILLSPA LSYTTKHLHN 900
DVEKEKKEKL PKEIEEDKLK REEEKRAEKS EDSSGTTGLS GLHRTYSQDC SFKNSMYHVG 960
DYVYVEPAEA NLQPHIVCIE RLWEDSAGEK WLYGCWFYRP NETFHLATRK FLEKEVFKSD 1020
YYNKVPVSKI LGKCVVMFVK EYFKLCPENF RDEDVFVCES RYSAKTKSFK KIKLWTMPIS 1080
SVRFVPRDVP LPVVRVASVF ANADKGDDEK NTDNSDDNRA EDNFNLEKEK EDVPVEMSNG 1140
EPGCHYFEQL RYNDMWLKVG DCVFIKSHGL VRPRVGRIEK VWVRDGAAYF YGPIFIHPEE 1200
TEHEPTKMFY KKEVFLSNLE ETCPMSCILG KCAVLSFKDF LSCRPTEIPE NDILLCESRY 1260
NESDKQMKKF KGLKRFSLSA KVVDDEIYYF RKPIIPQKEP SPLLEKKIQL LEAKFAELEG 1320
GDDDIEEMGE EDSEVIEAPS LPQLQTPLAN ELDLMPYTPP QSTPKSAKGS AKKESSKRKI 1380
NMSGYILFSS EMRAVIKAQH PDYSFGELSR LVGTEWRNLE TAKKAEYEGM MGGYPPGLPP 1440
LQGPVDGLVS MGSMQPLHPG G 1461 
Gene Ontology
 GO:0000776; C:kinetochore; IDA:MGI.
 GO:0005634; C:nucleus; IC:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0007507; P:heart development; IMP:MGI.
 GO:0001890; P:placenta development; IMP:MGI. 
Interpro
 IPR001025; BAH_dom.
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR009071; HMG_box_dom. 
Pfam
 PF01426; BAH
 PF00439; Bromodomain
 PF00505; HMG_box 
SMART
 SM00439; BAH
 SM00297; BROMO
 SM00398; HMG 
PROSITE
 PS51038; BAH
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS50118; HMG_BOX_2 
PRINTS
 PR00503; BROMODOMAIN.