UniProt Accession

 CSRP2_MOUSE; P97314; Q9CZG5 

Genbank Protein ID

 D88792; AK010626; AK012647; BC012663 

Genbank Nucleotide ID

 BAA13722.1; BAB27072.1; BAB28379.1; AAH12663.1 

Protein Name

 Cysteine and glycine-rich protein 2 

Protein Synonyms/Alias

 Cysteine-rich protein 2; CRP2; Double LIM protein 1; DLP-1 

Gene Name

 Csrp2 

Gene Synonyms/Alias

 Dlp1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
112	NTSKFAQKYGGAEKC	acetylation	[1, 2, 3]
137	EKIIGAGKPWHKNCF	acetylation	[3]
137	EKIIGAGKPWHKNCF	succinylation	[3]
173	YCKGCYAKNFGPKGF	acetylation	[2, 3]

Reference

 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system (By similarity). 

Sequence Annotation

 DOMAIN 10 61 LIM zinc-binding 1.
 DOMAIN 119 170 LIM zinc-binding 2.
 MOTIF 64 69 Nuclear localization signal (Potential).  

Keyword

 Complete proteome; Developmental protein; Differentiation; LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. 

Interpro

 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 

PRINTS