UniProt Accession

 ATAD1_RAT; Q505J9; B3STU2 

Genbank Protein ID

 BC094514; EF688601 

Genbank Nucleotide ID

 AAH94514.1; ABX10437.1 

Protein Name

 ATPase family AAA domain-containing protein 1 

Protein Synonyms/Alias

 Thorase 

Gene Name

 Atad1 

Gene Synonyms/Alias

 Npg6 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
274	AILKLILKNENVDRH	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA- stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent. 

Sequence Annotation

 NP_BIND 133 140 ATP (Potential).
 MOD_RES 322 322 Phosphoserine (By similarity).
 CROSSLNK 46 46 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 ATP-binding; Cell junction; Cell membrane; Complete proteome; Hydrolase; Isopeptide bond; Membrane; Nucleotide-binding; Peroxisome; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 361 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005778; C:peroxisomal membrane; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0045211; C:postsynaptic membrane; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; ISS:UniProtKB.
 GO:0007612; P:learning; ISS:UniProtKB.
 GO:0007613; P:memory; ISS:UniProtKB.
 GO:0051967; P:negative regulation of synaptic transmission, glutamatergic; ISS:UniProtKB.
 GO:0002092; P:positive regulation of receptor internalization; ISS:UniProtKB. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00004; AAA 

SMART

 SM00382; AAA 

PROSITE

 PS00674; AAA 

PRINTS