UniProt Accession

 KITH_ECOLI; P23331; Q0H0G7 

Genbank Protein ID

 X51523; X53733; X67326; DQ384607; U00096; AP009048 

Genbank Nucleotide ID

 CAA35907.1; CAA37765.1; CAA47741.1; ABD37701.1; AAC74320.1; BAA36118.1 

Protein Name

 Thymidine kinase 

Protein Synonyms/Alias

  

Gene Name

 tdk 

Gene Synonyms/Alias

 b1238; JW1226 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
142	SDKLVELKTICFCGR	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Phosphorylates both thymidine and deoxyuridine. 

Sequence Annotation

 NP_BIND 9 16 ATP (Probable).
 NP_BIND 87 90 ATP (By similarity).
 ACT_SITE 88 88 Proton acceptor (Potential).
 METAL 145 145 Zinc (By similarity).
 METAL 147 147 Zinc (By similarity).
 METAL 182 182 Zinc (By similarity).
 METAL 185 185 Zinc (By similarity).  

Keyword

 Allosteric enzyme; ATP-binding; Complete proteome; Cytoplasm; DNA synthesis; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Transferase; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 205 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0004797; F:thymidine kinase activity; IEA:HAMAP.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR001267; Thymidine_kinase.
 IPR020633; Thymidine_kinase_CS.
 IPR020634; Thymidine_kinase_subgr. 

Pfam

 PF00265; TK 

SMART

  

PROSITE

 PS00603; TK_CELLULAR_TYPE 

PRINTS