UniProt Accession

 CTBP1_MOUSE; O88712; Q3TAT1; Q3TDL5; Q3TUM5; Q91WI6; Q91YX3; Q9QYG2 

Genbank Protein ID

 AJ010483; AB033122; AK133816; AK160658; AK165276; AK170133; AK171650; BC013702; BC015071; BC042425 

Genbank Nucleotide ID

 CAA09219.1; BAA85180.1; BAE21859.1; BAE35946.1; BAE38115.1; BAE41586.1; BAE42587.1; AAH13702.1; AAH15071.1; AAH42425.1 

Protein Name

 C-terminal-binding protein 1 

Protein Synonyms/Alias

 CtBP1 

Gene Name

 Ctbp1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
273	RGGLVDEKALAQALK	ubiquitination	[1]
280	KALAQALKEGRIRGA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity). Co- repressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity. Functions in brown adipose tissue (BAT) differentiation. 

Sequence Annotation

 NP_BIND 180 185 NAD (By similarity).
 NP_BIND 237 243 NAD (By similarity).
 NP_BIND 264 266 NAD (By similarity).
 NP_BIND 315 318 NAD (By similarity).
 REGION 1 70 Interaction with GLIS2 1.
 REGION 288 360 Interaction with GLIS2 2.
 ACT_SITE 266 266 By similarity.
 ACT_SITE 295 295 By similarity.
 ACT_SITE 315 315 Proton donor (By similarity).
 BINDING 100 100 NAD (By similarity).
 BINDING 204 204 NAD (By similarity).
 BINDING 290 290 NAD (By similarity).
 MOD_RES 300 300 Phosphoserine (By similarity).
 MOD_RES 423 423 Phosphoserine (By similarity).
 CROSSLNK 429 429 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 ADP-ribosylation; Alternative splicing; Complete proteome; Cytoplasm; Differentiation; Direct protein sequencing; Isopeptide bond; NAD; Nucleus; Oxidoreductase; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 441 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0017053; C:transcriptional repressor complex; IDA:UniProtKB.
 GO:0051287; F:NAD binding; ISS:UniProtKB.
 GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
 GO:0001106; F:RNA polymerase II transcription corepressor activity; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0007030; P:Golgi organization; IEA:Compara.
 GO:0090241; P:negative regulation of histone H4 acetylation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0031065; P:positive regulation of histone deacetylation; IEA:Compara.
 GO:0051726; P:regulation of cell cycle; IEA:Compara.
 GO:0034401; P:regulation of transcription by chromatin organization; IEA:Compara.
 GO:0050872; P:white fat cell differentiation; IDA:UniProtKB. 

Interpro

 IPR006139; D-isomer_2_OHA_DH_cat_dom.
 IPR006140; D-isomer_2_OHA_DH_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00389; 2-Hacid_dh
 PF02826; 2-Hacid_dh_C 

SMART

  

PROSITE

 PS00065; D_2_HYDROXYACID_DH_1
 PS00670; D_2_HYDROXYACID_DH_2
 PS00671; D_2_HYDROXYACID_DH_3 

PRINTS