| Tag | Content |
|---|
| CPLM ID | CPLM-012421 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | TRAF3-interacting protein 1 |
Protein Synonyms/Alias | Microtubule-interacting protein associated with TRAF3; MIP-T3 |
Gene Name | Traf3ip1 |
Gene Synonyms/Alias | Mipt3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 126 | LSSDEAVKRVLAGDK | acetylation | [1] |
|
Reference | [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [ PMID: 23576753] |
Functional Description | Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (By similarity). |
Sequence Annotation | REGION 1 322 Abolishes microtubules binding when
REGION 229 625 DISC1-interaction domain (By similarity).
MOD_RES 409 409 Phosphoserine. |
Keyword | Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 625 AA |
Protein Sequence | MNAAVVRRTQ EALGKVIRRP PLTEKLLNKP PFRYLHDIIT EVIRITGFMK GLYTDAEMKS 60
ENVKDKDAKI SFLQKAIDVV MMVSGEPLAA KPARIVAGHE PERTNELLQL IGKCCLSKLS 120
SDEAVKRVLA GDKGDSRGRA QRTSKAQEPN NKSGKEEESR IHKEDKRSSE AKERSASAEH 180
KQKEELKEDS KPREKERDKE KAKEADRDRH RDPDRDRNRD GEREKARARA KDRDRNNRDR 240
DREAERDRER DRRSEGGKEK ERVKDRDRDR DKGRDRERRK SKNGEHTRDP DREKSRDADK 300
PEKKSSSSGE ISRKLSDGSF KDVKAEMEAD ISVGASRSST LKPSKRRSKH SLEGDSPSDA 360
EVEAGPAGQD KPEVMENAEV PSELPSSLRR IPRPGSARPA PPRVKRQEST ETLVVDRSGS 420
GKTVSSVIID SQNSDNEDDE QFVVEAAPQL SEIADIDMVP SGELEDEEKH GGLVKKILET 480
KKDYEKLQQS LKPGEKERSL IFESAWKKEK DIVSKEIEKL RVSIQTLCKS ALPLGKIMDY 540
IQEDVDAMQN ELQLWHSENR QHAEALSQEQ SITDSAVEPL KAELSELEQQ IRDQQDKICA 600
VKANILKNEE KIQKMVHSIN LSSRR 625 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |