CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020761
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methylmalonyl-CoA epimerase, mitochondrial 
Protein Synonyms/Alias
 DL-methylmalonyl-CoA racemase 
Gene Name
 Mcee 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
62VAVPDLEKASSFYRDacetylation[1, 2, 3]
116PITGFLQKNKAGGMHacetylation[2, 4]
116PITGFLQKNKAGGMHsuccinylation[4]
152RSLSDEAKIGAHGKPacetylation[1, 2, 3, 4, 5, 6]
152RSLSDEAKIGAHGKPsuccinylation[4]
158AKIGAHGKPVIFLHPacetylation[1, 2, 3]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [6] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Isomerase; Mitochondrion; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 178 AA 
Protein Sequence
MRRVVKAAAL AAGATGLFSR VQTSVAIGRS FSTPQSQFQE SSPVWKLGRL NHVAVAVPDL 60
EKASSFYRDV LGAQVSEVVP LPEHGVSVVF VNLGNTKMEL LHPLGSDSPI TGFLQKNKAG 120
GMHHVCIEVD NISAAVMDLK KKKIRSLSDE AKIGAHGKPV IFLHPKDCGG VLVELEQA 178 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004493; F:methylmalonyl-CoA epimerase activity; IEA:EC.
 GO:0046491; P:L-methylmalonyl-CoA metabolic process; IEA:Compara. 
Interpro
 IPR017515; MeMalonyl-CoA_epimerase. 
Pfam
  
SMART
  
PROSITE
  
PRINTS