CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007888
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable kynurenine--oxoglutarate transaminase BNA3 
Protein Synonyms/Alias
 Biosynthesis of nicotinic acid protein 3; Kynurenine aminotransferase 
Gene Name
 BNA3 
Gene Synonyms/Alias
 YJL060W; J1138 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
24RPKVVANKYFTSNTAacetylation[1]
425LLRFAVCKDDAYLENubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA) (By similarity). 
Sequence Annotation
 MOD_RES 271 271 N6-(pyridoxal phosphate)lysine (By  
Keyword
 3D-structure; Aminotransferase; Complete proteome; Cytoplasm; Mitochondrion; Pyridoxal phosphate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 444 AA 
Protein Sequence
MKQRFIRQFT NLMSTSRPKV VANKYFTSNT AKDVWSLTNE AAAKAANNSK NQGRELINLG 60
QGFFSYSPPQ FAIKEAQKAL DIPMVNQYSP TRGRPSLINS LIKLYSPIYN TELKAENVTV 120
TTGANEGILS CLMGLLNAGD EVIVFEPFFD QYIPNIELCG GKVVYVPINP PKELDQRNTR 180
GEEWTIDFEQ FEKAITSKTK AVIINTPHNP IGKVFTREEL TTLGNICVKH NVVIISDEVY 240
EHLYFTDSFT RIATLSPEIG QLTLTVGSAG KSFAATGWRI GWVLSLNAEL LSYAAKAHTR 300
ICFASPSPLQ EACANSINDA LKIGYFEKMR QEYINKFKIF TSIFDELGLP YTAPEGTYFV 360
LVDFSKVKIP EDYPYPEEIL NKGKDFRISH WLINELGVVA IPPTEFYIKE HEKAAENLLR 420
FAVCKDDAYL ENAVERLKLL KDYL 444 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0016212; F:kynurenine-oxoglutarate transaminase activity; IDA:SGD.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0034276; P:kynurenic acid biosynthetic process; IDA:SGD.
 GO:0097053; P:L-kynurenine catabolic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR004839; Aminotransferase_I/II.
 IPR004838; NHTrfase_class1_PyrdxlP-BS.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00155; Aminotran_1_2 
SMART
  
PROSITE
 PS00105; AA_TRANSFER_CLASS_1 
PRINTS