UniProt Accession

 B4E0J7_HUMAN; B4E0J7 

Genbank Protein ID

 AC139256; AK303405 

Genbank Nucleotide ID

 BAG64459.1 

Protein Name

 RNA polymerase I-specific transcription initiation factor RRN3 

Protein Synonyms/Alias

 cDNA FLJ52380, highly similar to RNA polymerase I-specific transcriptioninitiation factor RRN3 

Gene Name

 RRN3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
233	GSFLARAKFIPLITV	ubiquitination	[1]
298	QLLSGNLKEGLQYLQ	ubiquitination	[2]
386	PFDPCVLKRSKKFID	ubiquitination	[1, 3]
428	DEDDDFLKGEVPQND	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Initiation factor; Protein biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 469 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW. 

Interpro

 IPR007991; RNA_pol_I_trans_ini_fac_RRN3. 

Pfam

 PF05327; RRN3 

SMART

  

PROSITE

  

PRINTS