CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011392
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pre-rRNA-processing protein ESF1 
Protein Synonyms/Alias
 18S rRNA factor 1 
Gene Name
 ESF1 
Gene Synonyms/Alias
 YDR365C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
23AGIYSDPKFKNTKTKacetylation[1]
55QHKSKVDKYGRKIKNacetylation[1]
482NDEEEIEKNAKSKAEacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919
Functional Description
 Involved in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2. 
Sequence Annotation
 MOD_RES 86 86 Phosphoserine.
 MOD_RES 220 220 Phosphothreonine.
 MOD_RES 223 223 Phosphoserine.
 MOD_RES 225 225 Phosphoserine.
 MOD_RES 367 367 Phosphoserine.
 MOD_RES 369 369 Phosphoserine.
 MOD_RES 372 372 Phosphoserine.
 MOD_RES 542 542 Phosphothreonine.  
Keyword
 Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis; RNA-binding; rRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 628 AA 
Protein Sequence
MAGENPKKEG VDARFAGIYS DPKFKNTKTK DHKIKLDSRF SKKDLEVQHK SKVDKYGRKI 60
KNAQNNRELE DFDKYFEKEA ENDEDSEVNA KTVVDRARGE VPDDYVSSSD EFTSSDSESS 120
GESEVESEEE NEVEIENAKP ESGDISKNLA VVNLDWDHVK SEDLMITFSS FVPKGGKIER 180
VAIYPSEFGK ERMQREEVEG PPKELFQKKN KNKTSKKKKT DDSDSDMDIG IKDLYEEGDA 240
DKDVDSRALR QYQLDRLRYY YAIVYCSDTT TSKAIYDNCD GTEYESTANM FDLRYVPDGM 300
TFDDDVRDEC SILPKNYRPH QFSTDALQHS SVKLTWDETP ADRVEVAKRA FTQKEIDDMD 360
FKAYLASDSD ESDGQVDEEA KNKLKSLVGD FGFNSKKETP NDEDEEVDME ITFTPALEGG 420
NEKSSEDKEE TTIEKIRRKE KERRKARKQK VKELKQQSEK DKKSKLKSVN KKHTNDEEEI 480
EKNAKSKAEL ELLMDDDDDT ETQGTINNKA HFNMNEILRS EKEKHKKGRY QKKERIVEDT 540
FTPDLEDPRF KEVFEDHDFA IDPTQPEFKG TQAMSKILKE RSKRVKNKKR KLGGSENNMT 600
NNADDNEDIG NLVNKLKKKS KSSKKVKV 628 
Gene Ontology
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0003723; F:RNA binding; IDA:SGD.
 GO:0006364; P:rRNA processing; IMP:SGD. 
Interpro
 IPR012580; NUC153. 
Pfam
 PF08159; NUC153 
SMART
  
PROSITE
  
PRINTS