CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004632
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UDP-N-acetylmuramate--L-alanine ligase 
Protein Synonyms/Alias
 UDP-N-acetylmuramoyl-L-alanine synthetase 
Gene Name
 murC 
Gene Synonyms/Alias
 b0091; JW0089 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
434RTIRGRGKIDPILVPacetylation[1]
479ARSLAEIKLKPQTPEacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Cell wall formation. 
Sequence Annotation
 NP_BIND 126 132 ATP (Potential).  
Keyword
 3D-structure; ATP-binding; Cell cycle; Cell division; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Direct protein sequencing; Ligase; Nucleotide-binding; Peptidoglycan synthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 491 AA 
Protein Sequence
MNTQQLAKLR SIVPEMRRVR HIHFVGIGGA GMGGIAEVLA NEGYQISGSD LAPNPVTQQL 60
MNLGATIYFN HRPENVRDAS VVVVSSAISA DNPEIVAAHE ARIPVIRRAE MLAELMRFRH 120
GIAIAGTHGK TTTTAMVSSI YAEAGLDPTF VNGGLVKAAG VHARLGHGRY LIAEADESDA 180
SFLHLQPMVA IVTNIEADHM DTYQGDFENL KQTFINFLHN LPFYGRAVMC VDDPVIRELL 240
PRVGRQTTTY GFSEDADVRV EDYQQIGPQG HFTLLRQDKE PMRVTLNAPG RHNALNAAAA 300
VAVATEEGID DEAILRALES FQGTGRRFDF LGEFPLEPVN GKSGTAMLVD DYGHHPTEVD 360
ATIKAARAGW PDKNLVMLFQ PHRFTRTRDL YDDFANVLTQ VDTLLMLEVY PAGEAPIPGA 420
DSRSLCRTIR GRGKIDPILV PDPARVAEML APVLTGNDLI LVQGAGNIGK IARSLAEIKL 480
KPQTPEEEQH D 491 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IDA:EcoliWiki.
 GO:0000287; F:magnesium ion binding; IDA:EcoliWiki.
 GO:0008763; F:UDP-N-acetylmuramate-L-alanine ligase activity; IDA:EcoliWiki.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0009252; P:peptidoglycan biosynthetic process; IEA:HAMAP.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. 
Interpro
 IPR004101; Mur_ligase_C.
 IPR013221; Mur_ligase_cen.
 IPR000713; Mur_ligase_N.
 IPR016040; NAD(P)-bd_dom.
 IPR005758; UDP-N-AcMur_Ala_ligase. 
Pfam
 PF01225; Mur_ligase
 PF02875; Mur_ligase_C
 PF08245; Mur_ligase_M 
SMART
  
PROSITE
  
PRINTS