CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027048
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Medea 
Protein Synonyms/Alias
  
Gene Name
 Med 
Gene Synonyms/Alias
 Medea; CG1775 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
112DLHKNELKHVKYCAFsumoylation[1]
159SGPSRLVKDEYSAGPsumoylation[1]
222PTGRTIPKIEPQDGVsumoylation[1]
Reference
 [1] Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo.
 Miles WO, Jaffray E, Campbell SG, Takeda S, Bayston LJ, Basu SP, Li M, Raftery LA, Ashe MP, Hay RT, Ashe HL.
 Genes Dev. 2008 Sep 15;22(18):2578-90. [PMID: 18794353] 
Functional Description
  
Sequence Annotation
  
Keyword
 Nucleus; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 745 AA 
Protein Sequence
MVQMPPPPSN APTSADACLS IVHSLMCHRQ GGESEGFAKR AIESLVKKLK EKRDELDSLI 60
TAITTNGAHP SKCVTIQRTL DGRLQVAGRK GFPHVIYARI WRWPDLHKNE LKHVKYCAFA 120
FDLKCDSVCV NPYHYERVVS PGIDLSGLSL QSGPSRLVKD EYSAGPLVGS MDIDGNDIGT 180
IQHHPTQMVG PGGYGYPQGP SEYVGDANPM SAMFPTGRTI PKIEPQDGVA GSRGSWMVPP 240
PPRLGQPPQQ QQQQPQQQTP QPTQQQQAQS QAAAHSLPVP HGMPGMPGPM NPGPVMAPPP 300
PPQQAQNPQG NGVHHTQANS PTDPASALAM QQQQQQQQQQ QQQQQQQQQQ SGGVPNGSVN 360
AGGGAAAGGQ YYGQPPPVSQ MQGAGGGGTS VAPSVHAQQN GYVSQPGSAG SAPVGGGGVF 420
GTAQPTPQQP QQPPTGVQAN TGSAGAQAGA GGGAAGTWTG PNTLTYTQSM QPPDPRSLPG 480
GFWNSSLSGD LGSPQQTPPQ QQQQQQQPRL LSRQPPPEYW CSIAYFELDT QVGETFKVPS 540
AKPNVIIDGY VDPSGGNRFC LGALSNVHRT EQSERARLHI GKGVQLDLRG EGDVWLRCLS 600
DNSVFVQSYY LDREAGRTPG DAVHKIYPAA CIKVFDLRQC HQQMHSLATN AQAAAAAQAA 660
AVAGVANQQM GGGGRSMTAA AGIGVDDLRR LCILRLSFVK GWGPDYPRQS IKETPCWIEV 720
HLHRALQLLD EVLHAMPIDG PRAAA 745 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:FlyBase.
 GO:0005634; C:nucleus; IPI:FlyBase.
 GO:0005667; C:transcription factor complex; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0030509; P:BMP signaling pathway; TAS:FlyBase.
 GO:0008283; P:cell proliferation; IMP:FlyBase.
 GO:0009950; P:dorsal/ventral axis specification; IMP:FlyBase.
 GO:0042078; P:germ-line stem cell division; IMP:FlyBase.
 GO:0030718; P:germ-line stem cell maintenance; IMP:FlyBase.
 GO:0007507; P:heart development; TAS:FlyBase.
 GO:0007480; P:imaginal disc-derived leg morphogenesis; IMP:FlyBase.
 GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
 GO:0045705; P:negative regulation of salivary gland boundary specification; TAS:FlyBase.
 GO:0030707; P:ovarian follicle cell development; IMP:FlyBase.
 GO:0045887; P:positive regulation of synaptic growth at neuromuscular junction; IMP:FlyBase.
 GO:0031290; P:retinal ganglion cell axon guidance; IMP:FlyBase.
 GO:0035019; P:somatic stem cell maintenance; IMP:FlyBase.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:FlyBase. 
Interpro
 IPR013790; Dwarfin.
 IPR003619; MAD_homology1_Dwarfin-type.
 IPR013019; MAD_homology_MH1.
 IPR017855; SMAD_dom-like.
 IPR001132; SMAD_dom_Dwarfin-type.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF03165; MH1
 PF03166; MH2 
SMART
 SM00523; DWA
 SM00524; DWB 
PROSITE
 PS51075; MH1
 PS51076; MH2 
PRINTS