| Tag | Content |
|---|
| CPLM ID | CPLM-023336 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mediator of RNA polymerase II transcription subunit 26 |
Protein Synonyms/Alias | Mediator complex subunit 26; dARC70 |
Gene Name | MED26 |
Gene Synonyms/Alias | Arc70; CG1793; CG1823 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 436 | RGRKKGSKGVDALIA | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA gene. |
Sequence Annotation | DOMAIN 8 85 TFIIS N-terminal.
MOD_RES 204 204 Phosphoserine.
MOD_RES 258 258 Phosphoserine.
MOD_RES 421 421 Phosphoserine.
MOD_RES 541 541 Phosphothreonine.
MOD_RES 551 551 Phosphoserine.
MOD_RES 1177 1177 Phosphoserine.
MOD_RES 1179 1179 Phosphothreonine. |
Keyword | Activator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1483 AA |
Protein Sequence | MNQIEIQELT THLSQALDQN YDVVNMDAVL CVICALEGTT ITKEQLEATR LAKYINQLRR 60
RTKNEHLARR AKSLLKKWRE MVGIQQTATE NLAHPSQISS SQPALDLVKS PITSFITEPI 120
APSQQIVSDL HSNIDSAEPP LSGEHTLLHP NFSNLVNSIK DSDRHENIAI TTLHTHKDRR 180
HSHSIRSCHV ASPQPIVIDH SVNSVINLTD DSTVKINEAS VVIDIASDSD ENDNNGSLNP 240
KKLNSIVPAP LPIPSTPSSR QRKLKKEKRS KEREGQVATN TRFGAKASDG FQQAALTTDS 300
EIFSLSNSSM SSIVSGDATS SYSQNKSRLN SNELTFTGRF KAVDHLFRST ESGKHKIDEY 360
SAYDSNASCS RLSPSTVDEV KKAEHLFDAQ LTNTTANQIP MSAVSIGYES NTRHEYLESD 420
SPSQIPKRRG RKKGSKGVDA LIAKESSSLS QQIFFGGSTV KKVKTTKELF NEIQSRKLSV 480
SMQSSASNLS NSSTNRDLPS HTTFPRQTSS CSDTSMNSPH ILETLSGSAI FASKIDDLGN 540
TDSDTVTSDP SHDSNKSQEI KECTSLDSNS NSIQSLPLAN NRENLIPTNV NDITTQLMHL 600
IHSLNSPLSE IEIERVYQEK IIPCTCIVIE GVQGTLGESN NSTLDEQSYN AKISLNSKDN 660
LSCHNQDNYS TSQRSVNGEV IDTQPKLVKS IFDLDFDDND DPLYFIMDEI QKPIARADEL 720
KNNKSDTKNI NFGASAQNAS LNIIHFNDDA QQDNSNQERG KNETQNAIPA FTVHEDPDCL 780
ARQRFYIQTN KVTSFHINAL HNYYIPNING NWDSVESFTS FQSEHTIMDT MESYTVTNGA 840
DVVPKYGLLT SDRIRKDLSS LKSIKPYRVK NFTSLISPFL GVAKCLPTCR RARRRFKNFV 900
NSSTANDKIS NNFESLENMK TSFKNCNPLN VKIDGTTSAI YSHNENHVPM QVNTNVEQLP 960
PSQSFSSNAI SYNLLKLADD KVCHDGISDK SSNTGCQGNS PYSSSSSSSY SGRKEDQHII 1020
TKNLQNKNIQ LNSRKSDMKR RKRIYLENDS KKKKHYRKRI KTAVNRTFSN LHRNLYSIDS 1080
ENGMKNDYKN EYGNSNNEEY AIVQRPAGDG ENCSNHIVLT IKKTPSKINS PANSMTAFSP 1140
PSTSDGANLQ KSILDLRLED TNISQSITEI PQKKDLSKTD RIVHQSRSSA YRRIFRKPDK 1200
SQTKFIDLDL KHLFHLKANS PCISANAKLH NKLFFPHELS RDNTSGIRER LINYSSSSSS 1260
SYDDDSEVEN TSFLKKANVN KFSASNNRNL KTETETCAAT AISEFKFESD EDSILTSLGD 1320
SDIDIQDEIQ VINDKVDYCN DFQNNKMLES FNSIFVDSLR TNTKNASDNM GSSAHITSLE 1380
SLKPENADAI TRYCNNNNLG VNLSNELSNI SAKPLKSFDS TMKLPSLGIE HCTGIKTSSD 1440
MASTNIAEKK LTRIQQFKEW HQVLQLRSYN NEPLIVLPYV LLE 1483 |
Gene Ontology | GO:0016592; C:mediator complex; ISS:UniProtKB. GO:0003677; F:DNA binding; IEA:InterPro. GO:0001104; F:RNA polymerase II transcription cofactor activity; ISS:UniProtKB. GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase. GO:0006367; P:transcription initiation from RNA polymerase II promoter; ISS:FlyBase. |
Interpro | |
Pfam | |
SMART | |
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PRINTS | |