CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042015
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CUG triplet repeat, RNA binding protein 1, isoform CRA_c 
Protein Synonyms/Alias
 CUGBP Elav-like family member 1 
Gene Name
 CELF1 
Gene Synonyms/Alias
 CUGBP1; hCG_25183 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26LNSSPVSKKMNGTLDubiquitination[1]
27NSSPVSKKMNGTLDHubiquitination[1]
57VPRTWSEKDLRELFEubiquitination[1, 2]
97FVTFYTRKAALEAQNubiquitination[1]
145FIGMISKKCTENDIRubiquitination[3]
193AMAQTAIKAMHQAQTubiquitination[1, 4, 5, 6]
464SAKVFIDKQTNLSKCubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 514 AA 
Protein Sequence
MAAFKLDFLP EMMVDHCSLN SSPVSKKMNG TLDHPDQPDL DAIKMFVGQV PRTWSEKDLR 60
ELFEQYGAVY EINVLRDRSQ NPPQSKGCCF VTFYTRKAAL EAQNALHNMK VLPGMHHPIQ 120
MKPADSEKNN AVEDRKLFIG MISKKCTEND IRVMFSSFGQ IEECRILRGP DGLSRGCAFV 180
TFTTRAMAQT AIKAMHQAQT MEGCSSPMVV KFADTQKDKE QKRMAQQLQQ QMQQISAASV 240
WGNLAGLNTL GPQYLALYLQ LLQQTASSGN LNTLSSLHPM GGLNAMQLQN LAALAAAASA 300
AQNTPSGTNA LTTSSSPLSV LTSSAGSSPS SSSSNSVNPI ASLGALQTLA GATAGLNVGS 360
LAGMAALNGG LGSSGLSNGT GSTMEALTQA YSGIQQYAAA ALPTLYNQNL LTQQSIGAAG 420
SQKEGPEGAN LFIYHLPQEF GDQDLLQMFM PFGNVVSAKV FIDKQTNLSK CFGFVSYDNP 480
VSAQAAIQSM NGFQIGMKRL KVQLKRSKND SKPY 514 
Gene Ontology
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:InterPro. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS