CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010643
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Voltage-dependent P/Q-type calcium channel subunit alpha-1A 
Protein Synonyms/Alias
 Brain calcium channel I; BI; Calcium channel, L type, alpha-1 polypeptide isoform 4; Voltage-gated calcium channel subunit alpha Cav2.1 
Gene Name
 Cacna1a 
Gene Synonyms/Alias
 Caca1a; Cach4; Cacn3; Cacnl1a4; Ccha1a 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1898DLLVTPHKSTDLTVGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA). 
Sequence Annotation
 REPEAT 65 365 I.
 REPEAT 475 719 II.
 REPEAT 1182 1465 III.
 REPEAT 1502 1765 IV.
 REGION 385 402 Binding to the beta subunit (By
 MOD_RES 752 752 Phosphoserine.
 MOD_RES 1981 1981 Phosphoserine.
 MOD_RES 2027 2027 Phosphotyrosine.
 MOD_RES 2220 2220 Phosphoserine.
 MOD_RES 2273 2273 Phosphoserine.
 CARBOHYD 285 285 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1607 1607 N-linked (GlcNAc...) (Potential).  
Keyword
 Calcium; Calcium channel; Calcium transport; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2368 AA 
Protein Sequence
MARFGDEMPG RYGAGGGGSG PAAGVVVGAA GGRGAGGSRQ GGQPGAQRMY KQSMAQRART 60
MALYNPIPVR QNCLTVNRSL FLFSEDNVVR KYAKKITEWP PFEYMILATI IANCIVLALE 120
QHLPDDDKTP MSERLDDTEP YFIGIFCFEA GIKIVALGFA FHKGSYLRNG WNVMDFVVVL 180
TGILATVGTE FDLRTLRAVR VLRPLKLVSG IPSLQVVLKS IMKAMIPLLQ IGLLLFFAIL 240
IFAIIGLEFY MGKFHTTCFE EGTDDIQGES PAPCGTEEPA RTCPNGTKCQ PYWEGPNNGI 300
TQFDNILFAV LTVFQCITME GWTDLLYNSN DASGNTWNWL YFIPLIIIGS FFMLNLVLGV 360
LSGEFAKERE RVENRRAFLK LRRQQQIERE LNGYMEWISK AEEVILAEDE TDVEQRHPFD 420
GALRRATLKK SKTDLLNPEE AEDQLADIAS VGSPFARASI KSAKLENSTF FHKKERRMRF 480
YIRRMVKTQA FYWTVLSLVA LNTLCVAIVH YNQPEWLSDF LYYAEFIFLG LFMSEMFIKM 540
YGLGTRPYFH SSFNCFDCGV IIGSIFEVIW AVIKPGTSFG ISVLRALRLL RIFKVTKYWA 600
SLRNLVVSLL NSMKSIISLL FLLFLFIVVF ALLGMQLFGG QFNFDEGTPP TNFDTFPAAI 660
MTVFQILTGE DWNEVMYDGI KSQGGVQGGM VFSIYFIVLT LFGNYTLLNV FLAIAVDNLA 720
NAQELTKDEQ EEEEAANQKL ALQKAKEVAE VSPLSAANMS IAVKEQQKNQ KPTKSVWEQR 780
TSEMRKQNLL ASREALYGDA AERWPTPYAR PLRPDVKTHL DRPLVVDPQE NRNNNTNKSR 840
APEALRPTAR PRESARDPDA RRAWPGSPER APGREGPYGR ESEPQQREHA PPREHAPWDA 900
DTERAKAGDA PRRHTHRPVA EGEPRRHRAR RRPGDEPDDR PERRPRPRDA TRPARAADGE 960
GDDGERKRRH RHGPPAHDDR ERRHRRRKEN QGSGVPVSGP NLSTTRPIQQ DLGRQDLPLA 1020
EDLDNMKNNK LATGEPASPH DSLGHSGLPP SPAKIGNSTN PGPALATNPQ NAASRRTPNN 1080
PGNPSNPGPP KTPENSLIVT NPSSTQPNSA KTARKPEHMA VEIPPACPPL NHTVVQVNKN 1140
ANPDPLPKKE EEKKEEEEAD PGEDGPKPMP PYSSMFILST TNPLRRLCHY ILNLRYFEMC 1200
ILMVIAMSSI ALAAEDPVQP NAPRNNVLRY FDYVFTGVFT FEMVIKMIDL GLVLHQGAYF 1260
RDLWNILDFI VVSGALVAFA FTGNSKGKDI NTIKSLRVLR VLRPLKTIKR LPKLKAVFDC 1320
VVNSLKNVFN ILIVYMLFMF IFAVVAVQLF KGKFFHCTDE SKEFERDCRG KYLLYEKNEV 1380
KARDREWKKY EFHYDNVLWA LLTLFTVSTG EGWPQVLKHS VDATFENQGP SPGYRMEMSI 1440
FYVVYFVVFP FFFVNIFVAL IIITFQEQGD KMMEEYSLEK NERACIDFAI SAKPLTRHMP 1500
QNKQSFQYRM WQFVVSPPFE YTIMAMIALN TIVLMMKFYG ASVAYENALR VFNIVFTSLF 1560
SLECVLKVMA FGILNYFRDA WNIFDFVTVL GSITDILVTE FGNNFINLSF LRLFRAARLI 1620
KLLRQGYTIR ILLWTFVQSF KALPYVCLLI AMLFFIYAII GMQVFGNIGI DGEDEDSDED 1680
EFQITEHNNF RTFFQALMLL FRSATGEAWH NIMLSCLSGK PCDKNSGILT ADCGNEFAYF 1740
YFVSFIFLCS FLMLNLFVAV IMDNFEYLTR DSSILGPHHL DEYVRVWAEY DPAACGRIHY 1800
KDMYSLLRVI SPPLGLGKKC PHRVACKRLL RMDLPVADDN TVHFNSTLMA LIRTALDIKI 1860
AKGGADKQQM DAELRKEMMA IWPNLSQKTL DLLVTPHKST DLTVGKIYAA MMIMEYYRQS 1920
KAKKLQAMRE EQNRTPLMFQ RMEPPSPTQE GGPSQNALPS TQLDPGGGLM AHEGGMKESP 1980
SWVTQRAQEM FQKTGTWSPE RGPPIDMPNS QPNSQSVEMR EMGTDGYSDS EHYLPMEGQT 2040
RAASMPRLPA ENQRRRGRPR GNDLSTISDT SPMKRSASVL GPKARRLDDY SLERVPPEEN 2100
QRYHQRRRDR GHRTSERSLG RYTDVDTGLG TDLSMTTQSG DLPSKDRDQD RGRPKDRKHR 2160
PHHHHHHHHH HPPAPDRDRY AQERPDTGRA RAREQRWSRS PSEGREHTTH RQGSSSVSGS 2220
PAPSTSGTST PRRGRRQLPQ TPCTPRPLVS YSPAPRRPAA RRMAGPAAPP GGSPRGCRRA 2280
PRWPAHAPEG PRPRGADYTE PDSPREPPGG AHDPAPRSPR TPRAAGCASP RHGRRLPNGY 2340
YAGHGAPRPR TARRGAHDAY SESEDDWC 2368 
Gene Ontology
 GO:0030425; C:dendrite; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0005891; C:voltage-gated calcium channel complex; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0008331; F:high voltage-gated calcium channel activity; IMP:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007628; P:adult walking behavior; IMP:MGI.
 GO:0048266; P:behavioral response to pain; IMP:MGI.
 GO:0017156; P:calcium ion-dependent exocytosis; IMP:MGI.
 GO:0048791; P:calcium ion-dependent exocytosis of neurotransmitter; IMP:MGI.
 GO:0016049; P:cell growth; IMP:MGI.
 GO:0030644; P:cellular chloride ion homeostasis; IMP:MGI.
 GO:0021679; P:cerebellar molecular layer development; IMP:MGI.
 GO:0021702; P:cerebellar Purkinje cell differentiation; IMP:MGI.
 GO:0021590; P:cerebellum maturation; IMP:MGI.
 GO:0048813; P:dendrite morphogenesis; IMP:MGI.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; ISS:UniProtKB.
 GO:0014051; P:gamma-aminobutyric acid secretion; IMP:MGI.
 GO:0007214; P:gamma-aminobutyric acid signaling pathway; IMP:MGI.
 GO:0006006; P:glucose metabolic process; IMP:MGI.
 GO:0042445; P:hormone metabolic process; IMP:MGI.
 GO:0051899; P:membrane depolarization; IMP:MGI.
 GO:0050883; P:musculoskeletal movement, spinal reflex action; IMP:MGI.
 GO:0032353; P:negative regulation of hormone biosynthetic process; IMP:MGI.
 GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
 GO:0007274; P:neuromuscular synaptic transmission; IMP:MGI.
 GO:0042133; P:neurotransmitter metabolic process; IMP:MGI.
 GO:0043113; P:receptor clustering; IMP:MGI.
 GO:0014056; P:regulation of acetylcholine secretion; IMP:MGI.
 GO:0050770; P:regulation of axonogenesis; IMP:MGI.
 GO:0017158; P:regulation of calcium ion-dependent exocytosis; IDA:MGI.
 GO:0060024; P:rhythmic synaptic transmission; IMP:MGI.
 GO:0021522; P:spinal cord motor neuron differentiation; IMP:MGI.
 GO:0000096; P:sulfur amino acid metabolic process; IMP:MGI.
 GO:0007416; P:synapse assembly; IMP:MGI.
 GO:0035249; P:synaptic transmission, glutamatergic; IMP:MGI.
 GO:0021750; P:vestibular nucleus development; IMP:MGI. 
Interpro
 IPR017956; AT_hook_DNA-bd_motif.
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom.
 IPR014873; VDCC_a1su_IQ.
 IPR005448; VDCC_P/Q_a1su.
 IPR002077; VDCCAlpha1. 
Pfam
 PF08763; Ca_chan_IQ
 PF00520; Ion_trans 
SMART
 SM00384; AT_hook
 SM01062; Ca_chan_IQ 
PROSITE
  
PRINTS
 PR00167; CACHANNEL.
 PR01632; PQVDCCALPHA1.