CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009116
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sestrin-3 
Protein Synonyms/Alias
  
Gene Name
 SESN3 
Gene Synonyms/Alias
 SEST3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
47PSAFIPEKEVVQANTubiquitination[1]
378IGHLLDEKFRMVYNLubiquitination[2, 3, 4]
438RSLKVYIKTVTCYPEubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 492 AA 
Protein Sequence
MNRGGGSPSA AANYLLCTNC RKVLRKDKRI RVSQPLTRGP SAFIPEKEVV QANTVDERTN 60
FLVEEYSTSG RLDNITQVMS LHTQYLESFL RSQFYMLRMD GPLPLPYRHY IAIMAAARHQ 120
CSYLINMHVD EFLKTGGIAE WLNGLEYVPQ RLKNLNEINK LLAHRPWLIT KEHIQKLVKT 180
GENNWSLPEL VHAVVLLAHY HALASFVFGS GINPERDPEI SNGFRLISVN NFCVCDLAND 240
NNIENASLSG SNFGIVDSLS ELEALMERMK RLQEEREDEE ASQEEMSTRF EKEKKESLFV 300
VSGDTFHSFP HSDFEDDMII TSDVSRYIED PGFGYEDFAR RGEEHLPTFR AQDYTWENHG 360
FSLVNRLYSD IGHLLDEKFR MVYNLTYNTM ATHEDVDTTM LRRALFNYVH CMFGIRYDDY 420
DYGEVNQLLE RSLKVYIKTV TCYPERTTKR MYDSYWRQFK HSEKVHVNLL LMEARMQAEL 480
LYALRAITRH LT 492 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0007050; P:cell cycle arrest; IEA:InterPro. 
Interpro
 IPR006730; PA26. 
Pfam
 PF04636; PA26 
SMART
  
PROSITE
  
PRINTS