CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003970
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase SCH9 
Protein Synonyms/Alias
  
Gene Name
 SCH9 
Gene Synonyms/Alias
 KOM1; YHR205W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
420EVLRLLGKGTFGQVYubiquitination[1]
441TQRIYAMKVLSKKVIubiquitination[1]
623NNQKMYQKIAFGKVKubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway. Regulates both BCY1 phosphorylation and MPK1 activity. 
Sequence Annotation
 DOMAIN 185 361 C2.
 DOMAIN 412 671 Protein kinase.
 DOMAIN 672 748 AGC-kinase C-terminal.
 NP_BIND 418 426 ATP (By similarity).
 ACT_SITE 538 538 Proton acceptor (By similarity).
 BINDING 441 441 ATP (By similarity).
 MOD_RES 723 723 Phosphothreonine.
 MOD_RES 726 726 Phosphoserine.  
Keyword
 ATP-binding; cAMP; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 824 AA 
Protein Sequence
MMNFFTSKSS NQDTGFSSQH QHPNGQNNGN NNSSTAGNDN GYPCKLVSSG PCASSNNGAL 60
FTNFTLQTAT PTTAISQDLY AMGTTGITSE NALFQMKSMN NGISSVNNNN SNTPTIITTS 120
QEETNAGNVH GDTGGNSLQN SEDDNFSSSS TTKCLLSSTS SLSINQREAA AAAYGPDTDI 180
PRGKLEVTII EARDLVTRSK DSQPYVVCTF ESSEFISNGP ESLGAINNNN NNNNNNQHNQ 240
NQHINNNNEN TNPDAASQHH NNNSGWNGSQ LPSIKEHLKK KPLYTHRSSS QLDQLNSCSS 300
VTDPSKRSSN SSSGSSNGPK NDSSHPIWHH KTTFDVLGSH SELDISVYDA AHDHMFLGQV 360
RLYPMIHNLA HASQHQWHSL KPRVIDEVVS GDILIKWTYK QTKKRHYGPQ DFEVLRLLGK 420
GTFGQVYQVK KKDTQRIYAM KVLSKKVIVK KNEIAHTIGE RNILVTTASK SSPFIVGLKF 480
SFQTPTDLYL VTDYMSGGEL FWHLQKEGRF SEDRAKFYIA ELVLALEHLH DNDIVYRDLK 540
PENILLDANG NIALCDFGLS KADLKDRTNT FCGTTEYLAP ELLLDETGYT KMVDFWSLGV 600
LIFEMCCGWS PFFAENNQKM YQKIAFGKVK FPRDVLSQEG RSFVKGLLNR NPKHRLGAID 660
DGRELRAHPF FADIDWEALK QKKIPPPFKP HLVSETDTSN FDPEFTTAST SYMNKHQPMM 720
TATPLSPAMQ AKFAGFTFVD ESAIDEHVNN NRKFLQNSYF MEPGSFIPGN PNLPPDEDVI 780
DDDGDEDIND GFNQEKNMNN SHSQMDFDGD QHMDDEFVSG RFEI 824 
Gene Ontology
 GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IGI:SGD.
 GO:0001324; P:age-dependent response to oxidative stress involved in chronological cell aging; IMP:SGD.
 GO:0060963; P:positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter; IMP:SGD.
 GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter; IMP:SGD.
 GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter; IMP:SGD.
 GO:0008361; P:regulation of cell size; IMP:SGD.
 GO:0032880; P:regulation of protein localization; IMP:SGD.
 GO:0047484; P:regulation of response to osmotic stress; IMP:SGD.
 GO:0043619; P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IMP:SGD.
 GO:0001302; P:replicative cell aging; IMP:SGD. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR011009; Kinase-like_dom.
 IPR017892; Pkinase_C.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00168; C2
 PF00069; Pkinase
 PF00433; Pkinase_C 
SMART
 SM00239; C2
 SM00133; S_TK_X
 SM00220; S_TKc 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS50004; C2
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS