| Tag | Content |
|---|
| CPLM ID | CPLM-007994 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | LIM and senescent cell antigen-like-containing domain protein 1 |
Protein Synonyms/Alias | Particularly interesting new Cys-His protein 1; PINCH-1; Renal carcinoma antigen NY-REN-48 |
Gene Name | LIMS1 |
Gene Synonyms/Alias | PINCH; PINCH1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 199 | LGKYICQKCHAIIDE | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation. |
Sequence Annotation | DOMAIN 10 62 LIM zinc-binding 1.
DOMAIN 71 121 LIM zinc-binding 2.
DOMAIN 135 184 LIM zinc-binding 3.
DOMAIN 193 243 LIM zinc-binding 4.
DOMAIN 252 303 LIM zinc-binding 5.
MOD_RES 2 2 N-acetylalanine. |
Keyword | 3D-structure; Acetylation; Alternative splicing; Cell junction; Cell membrane; Complete proteome; Direct protein sequencing; LIM domain; Membrane; Metal-binding; Reference proteome; Repeat; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 325 AA |
Protein Sequence | MAFSGRARPC IIPENEEIPR AALNTVHEAN GTEDERAVSK LQRRHSDVKV YKEFCDFYAK 60
FNMANALASA TCERCKGGFA PAEKIVNSNG ELYHEQCFVC AQCFQQFPEG LFYEFEGRKY 120
CEHDFQMLFA PCCHQCGEFI IGRVIKAMNN SWHPECFRCD LCQEVLADIG FVKNAGRHLC 180
RPCHNREKAR GLGKYICQKC HAIIDEQPLI FKNDPYHPDH FNCANCGKEL TADARELKGE 240
LYCLPCHDKM GVPICGACRR PIEGRVVNAM GKQWHVEHFV CAKCEKPFLG HRHYERKGLA 300
YCETHYNQLF GDVCFHCNRV IEGDVVSALN KAWCVNCFAC STCNTKLTLK NKFVEFDMKP 360
VCKKCYEKFP LELKKRLKKL AETLGRK 387 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005925; C:focal adhesion; IDA:UniProtKB. GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0008270; F:zinc ion binding; IDA:UniProtKB. GO:0007569; P:cell aging; TAS:ProtInc. GO:0034329; P:cell junction assembly; TAS:Reactome. GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:UniProtKB. GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB. |
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