| Tag | Content |
|---|
| CPLM ID | CPLM-017820 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium-coupled neutral amino acid transporter 4 |
Protein Synonyms/Alias | Amino acid transporter A3; Na(+)-coupled neutral amino acid transporter 4; Solute carrier family 38 member 4; System A amino acid transporter 3 |
Gene Name | Slc38a4 |
Gene Synonyms/Alias | Ata3; Nat3; Snat4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 51 | NEDAESQKFLTNGFL | ubiquitination | [1] | | 60 | LTNGFLGKKKLADYA | ubiquitination | [1] | | 61 | TNGFLGKKKLADYAD | ubiquitination | [1] | | 446 | ITLLFPRKPFSWLKH | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by Ser, His, Gly, Cys, Asn, Thr, Pro, Gln and Met. May mediate sodium- independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with lower transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5. |
Sequence Annotation | MOD_RES 49 49 Phosphoserine.
CARBOHYD 260 260 N-linked (GlcNAc...) (Potential).
CARBOHYD 264 264 N-linked (GlcNAc...) (Potential).
CARBOHYD 276 276 N-linked (GlcNAc...) (Potential).
DISULFID 249 321 |
Keyword | Amino-acid transport; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 547 AA |
Protein Sequence | MDPMELNNVS IEPDGDSCSG DSIQDSYTGM ENSDKDAMNS QFANEDAESQ KFLTNGFLGK 60
KKLADYADEH HPGMTSFGMS SFNLSNAIMG SGILGLSYAM ANTGIILFII MLLTVAILSL 120
YSVHLLLKTA KEGGSLIYEK LGEKAFGWPG KIGAFISITM QNIGAMSSYL FIIKYELPEV 180
IRAFMGLEEN TGEWYLNGNY LVLFVSVGII LPLSLLKNLG YLGYTSGFSL SCMVFFVSVV 240
IYKKFQIPCP LPALDHNNGN LTFNNTLPIH MISLPNDSES SGVNFMMDYA HHNPAGLDEK 300
QVAGPLHSNG VEYEAQGAEK CQPKYFVFNS RTAYAIPILA FAFVCHPEVL PIYSELKDRS 360
RRKMQTVSNI SISGMLVMYL LAALFGYLSF YGDVEDELLH AYSKVYTFDT ALLMVRLAVL 420
VAVTLTVPIV LFPIRTSVIT LLFPRKPFSW LKHFGIAAII IALNNILVIL VPTIKYIFGF 480
IGASSATMLI FILPAAFYLK LVKKEPLRSP QKIGALVFLV TGIIFMMGSM ALIILDWIYN 540
PPNPNHH 547 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0015171; F:amino acid transmembrane transporter activity; IEA:Compara. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |