CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031031
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 26 member 6 
Protein Synonyms/Alias
 cDNA FLJ53405, highly similar to Solute carrier family 26 member 6 
Gene Name
 SLC26A6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
499VAEYSEAKEVRGVKVubiquitination[1, 2, 3]
593SNNVEDCKMMQVSSGubiquitination[2]
602MQVSSGDKMEDATANubiquitination[1, 2, 3]
615ANGQEDSKAPDGSTLubiquitination[1, 2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 723 AA 
Protein Sequence
MGLADASGPR DTQALLSATQ AMDLRRRDYH MERPLLNQEH LEELGRWGSA PRTHQWRTWL 60
QCSRARAYAL LLQHLPVLVW LPRYPVRDWL LGDLLSGLSV AIMQLPQGLA YALLAGLPPV 120
FGLYSSFYPV FIYFLFGTSR HISVATPGPL PLLTAPGRPT GGAGPDPLRL RGHLPVRTSC 180
PRLYHSCSCA GLRLTAQVCV WPPSEQPLWA TVPHLLLEVC WKLPQSKVGT VVTAAVAGVV 240
LVVVKLLNDK LQQQLPMPIP GELLTLIGAT GISYGMGLKH RFEVDVVGNI PAGLVPPVAP 300
NTQLFSKLVG SAFTIAVVGF AIAISLGKIF ALRHGYRVDS NQELVALGLS NLIGGIFQCF 360
PVSCSMSRSL VQESTGGNSQ VAGAISSLFI LLIIVKLGEL FHDLPKAVLA AIIIVNLKGM 420
LRQLSDMRSL WKANRADLLI WLVTFTATIL LNLDLGLVVA VIFSLLLVVV RTQMPHYSVL 480
GQVPDTDIYR DVAEYSEAKE VRGVKVFRSS ATVYFANAEF YSDALKQRCG VDVDFLISQK 540
KKLLKKQEQL KLKQLQKEEK LRKQAASPKG ASVSINVNTS LEDMRSNNVE DCKMMQVSSG 600
DKMEDATANG QEDSKAPDGS TLKALGLPQP DFHSLILDLG ALSFVDTVCL KSLKNIFHDF 660
REIEVEVYMA ACHSPVVSQL EAGHFFDASI TKKHLFASVH DAVTFALQHP RPVPDSPVSV 720
TRL 723 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
 GO:0008272; P:sulfate transport; IEA:InterPro. 
Interpro
 IPR018045; S04_transporter_CS.
 IPR002645; STAS_dom.
 IPR011547; Sulph_transpt. 
Pfam
 PF01740; STAS
 PF00916; Sulfate_transp 
SMART
  
PROSITE
 PS01130; SLC26A
 PS50801; STAS 
PRINTS