UniProt Accession

 DLGP5_HUMAN; Q15398; A8MTM6; B4DRM8; Q86T11; Q8NG58 

Genbank Protein ID

 AB076695; D13633; BX248255; BT007344; AK299338; AL139316; CH471061; BC010658; BC016276 

Genbank Nucleotide ID

 BAB97376.1; BAA02797.3; CAD62583.1; AAP36008.1; BAG61340.1; EAW80664.1; AAH10658.2; AAH16276.2 

Protein Name

 Disks large-associated protein 5 

Protein Synonyms/Alias

 DAP-5; Discs large homolog 7; Disks large-associated protein DLG7; Hepatoma up-regulated protein; HURP 

Gene Name

 DLGAP5 

Gene Synonyms/Alias

 DLG7; KIAA0008 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
411	NLNGLPIKEVPSLER	ubiquitination	[1]
495	LVDDCEYKRGIKETT	ubiquitination	[1]
785	ILEEGETKISQSELF	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. 

Sequence Annotation

 MOD_RES 67 67 Phosphoserine; by CDK1.
 MOD_RES 219 219 Phosphothreonine (By similarity).
 MOD_RES 326 326 Phosphothreonine.
 MOD_RES 329 329 Phosphothreonine; by CDK1.
 MOD_RES 338 338 Phosphothreonine.
 MOD_RES 401 401 Phosphothreonine; by CDK1.
 MOD_RES 402 402 Phosphothreonine; by CDK1.
 MOD_RES 618 618 Phosphoserine; by CDK1.
 MOD_RES 627 627 Phosphoserine; by AURKA.
 MOD_RES 639 639 Phosphothreonine; by CDK1.
 MOD_RES 642 642 Phosphoserine; by CDK1.
 MOD_RES 662 662 Phosphoserine.
 MOD_RES 725 725 Phosphoserine; by AURKA.
 MOD_RES 757 757 Phosphoserine; by AURKA.
 MOD_RES 759 759 Phosphothreonine; by CDK1.
 MOD_RES 777 777 Phosphoserine.
 MOD_RES 784 784 Phosphothreonine.
 MOD_RES 806 806 Phosphoserine.
 MOD_RES 812 812 Phosphoserine.
 MOD_RES 830 830 Phosphoserine; by AURKA.
 MOD_RES 839 839 Phosphoserine; by CDK1.  

Keyword

 Alternative splicing; Cell cycle; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 846 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0031616; C:spindle pole centrosome; IDA:UniProtKB.
 GO:0004721; F:phosphoprotein phosphatase activity; IDA:UniProtKB.
 GO:0008283; P:cell proliferation; NAS:UniProtKB.
 GO:0007267; P:cell-cell signaling; IEA:InterPro.
 GO:0000087; P:M phase of mitotic cell cycle; IDA:UniProtKB.
 GO:0007079; P:mitotic chromosome movement towards spindle pole; NAS:UniProtKB.
 GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; NAS:UniProtKB. 

Interpro

 IPR005026; GKAP. 

Pfam

 PF03359; GKAP 

SMART

  

PROSITE

  

PRINTS