UniProt Accession

 TRFE_HUMAN; P02787; O43890; Q1HBA5; Q9NQB8; Q9UHV0 

Genbank Protein ID

 M12530; M17611; M17610; M17614; M17612; M17613; S95936; AF288144; AF294270; AF294271; AF288139; AF288140; AF288141; AF288142; AF288143; AY308797; DQ525716; AC080128; AC083905; CH471052; BC059367; M21569; M15673; M21570; X04600; AJ252279; M11372; M11361; M11362; M11363; M11364; M11365; M11366; M11367; M11368; M11369; M11370; M11371; AF118063; M12525; U88581; AF058327; M26641 

Genbank Nucleotide ID

 AAA61140.1; AAA61147.1; AAA61147.1; AAA61148.1; AAA61148.1; AAA61148.1; AAB22049.1; AAK77664.1; AAK77664.1; AAK77664.1; AAK77664.1; AAK77664.1; AAK77664.1; AAK77664.1; AAK77664.1; AAP45055.1; ABF47110.1; EAW79167.1; AAH59367.1; AAA61143.2; AAA61143.2; AAA61145.1; CAA28265.1; CAB96907.1; AAA61141.1; AAA61141.1; AAA61141.1; AAA61141.1; AAA61141.1; AAA61141.1; AAA61141.1; AAA61141.1; AAA61141.1; AAA61141.1; AAA61141.1; AAA61141.1; AAF22007.1; AAA61142.1; AAB97880.1; AAC63506.1; AAA61233.1 

Protein Name

 Serotransferrin 

Protein Synonyms/Alias

 Transferrin; Beta-1 metal-binding globulin; Siderophilin 

Gene Name

 TF 

Gene Synonyms/Alias

 PRO1400 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
61	PSVACVKKASYLDCI	glycation	[1]
122	YAVAVVKKDSGFQMN	glycation	[1]
215	SGAFKCLKDGAGDVA	glycation	[1]
225	AGDVAFVKHSTIFEN	glycation	[1]
258	RKPVDEYKDCHLAQV	glycation	[1]
297	QEHFGKDKSKEFQLF	glycation	[1]
299	HFGKDKSKEFQLFSS	glycation	[1]
315	HGKDLLFKDSAHGFL	glycation	[1]
359	EAPTDECKPVKWCAL	acetylation	[2]
553	KGDVAFVKHQTVPQN	glycation	[1]
659	DDTVCLAKLHDRNTY	glycation	[1]
668	HDRNTYEKYLGEEYV	glycation	[1]
676	YLGEEYVKAVGNLRK	glycation	[1]
683	KAVGNLRKCSTSSLL	glycation	[1]

Reference

 [1] Proteomic profiling of nonenzymatically glycated proteins in human plasma and erythrocyte membranes.
 Zhang Q, Tang N, Schepmoes AA, Phillips LS, Smith RD, Metz TO.
 J Proteome Res. 2008 May;7(5):2025-32. [PMID: 18396901]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. 

Sequence Annotation

 DOMAIN 25 347 Transferrin-like 1.
 DOMAIN 361 683 Transferrin-like 2.
 METAL 82 82 Iron 1.
 METAL 114 114 Iron 1.
 METAL 207 207 Iron 1.
 METAL 268 268 Iron 1.
 METAL 411 411 Iron 2 (By similarity).
 METAL 445 445 Iron 2 (By similarity).
 METAL 536 536 Iron 2 (By similarity).
 METAL 604 604 Iron 2 (By similarity).
 BINDING 139 139 Carbonate 1.
 BINDING 143 143 Carbonate 1.
 BINDING 145 145 Carbonate 1; via amide nitrogen.
 BINDING 146 146 Carbonate 1; via amide nitrogen.
 BINDING 471 471 Carbonate 2 (By similarity).
 BINDING 475 475 Carbonate 2 (By similarity).
 BINDING 477 477 Carbonate 2; via amide nitrogen (By
 BINDING 478 478 Carbonate 2; via amide nitrogen (By
 MOD_RES 42 42 Omega-N-methylated arginine (By
 CARBOHYD 51 51 O-linked (GalNAc...).
 CARBOHYD 432 432 N-linked (GlcNAc...) (complex).
 CARBOHYD 630 630 N-linked (GlcNAc...) (complex).
 DISULFID 28 67
 DISULFID 38 58
 DISULFID 137 213
 DISULFID 156 350
 DISULFID 177 193
 DISULFID 180 196
 DISULFID 190 198
 DISULFID 246 260
 DISULFID 358 615
 DISULFID 364 396
 DISULFID 374 387
 DISULFID 421 693
 DISULFID 437 656
 DISULFID 469 542
 DISULFID 493 684
 DISULFID 503 517
 DISULFID 514 525
 DISULFID 582 596
 DISULFID 634 639  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Ion transport; Iron; Iron transport; Metal-binding; Methylation; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 698 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
 GO:0009925; C:basal plasma membrane; IDA:UniProtKB.
 GO:0005905; C:coated pit; IDA:UniProtKB.
 GO:0005769; C:early endosome; IDA:UniProtKB.
 GO:0030139; C:endocytic vesicle; IDA:MGI.
 GO:0010008; C:endosome membrane; TAS:Reactome.
 GO:0005576; C:extracellular region; NAS:UniProtKB.
 GO:0005770; C:late endosome; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0055037; C:recycling endosome; IDA:UniProtKB.
 GO:0034774; C:secretory granule lumen; TAS:Reactome.
 GO:0008199; F:ferric iron binding; IEA:InterPro.
 GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0002576; P:platelet degranulation; TAS:Reactome.
 GO:0033572; P:transferrin transport; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome. 

Interpro

 IPR016357; Transferrin.
 IPR001156; Transferrin_fam.
 IPR018195; Transferrin_Fe_BS. 

Pfam

 PF00405; Transferrin 

SMART

 SM00094; TR_FER 

PROSITE

 PS00205; TRANSFERRIN_LIKE_1
 PS00206; TRANSFERRIN_LIKE_2
 PS00207; TRANSFERRIN_LIKE_3
 PS51408; TRANSFERRIN_LIKE_4 

PRINTS

 PR00422; TRANSFERRIN.