| Tag | Content |
|---|
| CPLM ID | CPLM-024147 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein fem-1 homolog A-A |
Protein Synonyms/Alias | FEM1a-A; FEM1-alpha-A |
Gene Name | Fem1aa |
Gene Synonyms/Alias | Fem1a |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 15 | YNAAHDGKLPLLQKL | ubiquitination | [1] | | 296 | LGATYVDKKRDLLGA | ubiquitination | [1] | | 609 | AYELLDSKLLAKSTV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. May participate in antiinflammatory signaling via its interaction with PTGER4 (By similarity). |
Sequence Annotation | REPEAT 2 31 ANK 1.
REPEAT 40 70 ANK 2.
REPEAT 82 111 ANK 3.
REPEAT 115 145 ANK 4.
REPEAT 149 178 ANK 5.
REPEAT 182 211 ANK 6.
REPEAT 214 243 ANK 7.
REPEAT 283 317 TPR 1.
REPEAT 375 408 TPR 2.
REPEAT 519 561 ANK 8.
REPEAT 565 594 ANK 9. |
Keyword | ANK repeat; Complete proteome; Cytoplasm; Reference proteome; Repeat; TPR repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 654 AA |
Protein Sequence | MDLHTAVYNA AHDGKLPLLQ KLLAGRGREE LEELLGEVAG GGTPLLIAAR RGHLDVVEYL 60
VDHCGASVEA SGSVHFDGET IEGAPPLWAA SAAGHLAVVR SLLRRGASVN RTTRTNSTPL 120
RAACFDGHLD VVRYLVGEHK ADLEVANRHG HTCLMISCYK GHREIARYLL ERGAQVNRRS 180
AKGNTALHDC AESGSLEILQ LLLGCHARME RDGYGMTPLL AASVTGHTNI VEYLIQEQPG 240
HEQLSGTELP GEGSSQVAGN HCSTPEEAEP YESCCPTSRE AAVEALELLG ATYVDKKRDL 300
LGALKHWRRA MELRHQGGGY LPKPEPQQLV LAYDYSREVT TPQELEALIT DPDEMRMQAL 360
LIRERILGPS HPDTSYYIRY RGAVYADSGN FERCIRLWKY ALDMQQNNLE PLSPMTASSF 420
LSFAELFSYV LQDRSAKGNL GMQLGFADLM GVLSKGVREV ERALQLPKEP GDSAQFTKAI 480
AIILHLLYLL EKVECTPSQE HLKHQTVYRL LKCAPRGKNG FTPLHMAVDK ETTNVGRYRV 540
GVFPSLQVVK VLLDCGADPD SRDFDNNTPL HIAAQNNCPA IMDALIEAGA HMDATNAFKK 600
TAYELLDSKL LAKSTVQPFN YVTLQCLAAR ALDRNKVPYK GFIPEELEAF IQLH 654 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. GO:0050728; P:negative regulation of inflammatory response; IGI:MGI. GO:0043407; P:negative regulation of MAP kinase activity; IDA:MGI. GO:0051438; P:regulation of ubiquitin-protein ligase activity; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |