UniProt Accession

 NC2B_RAT; Q5XI68 

Genbank Protein ID

 BC083822 

Genbank Nucleotide ID

 AAH83822.1 

Protein Name

 Protein Dr1 

Protein Synonyms/Alias

 Down-regulator of transcription 1; Negative cofactor 2-beta; NC2-beta; TATA-binding protein-associated phosphoprotein 

Gene Name

 Dr1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
128	QQQELFAKARQQQAE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). 

Sequence Annotation

 MOTIF 100 103 Nuclear localization signal (Potential).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 166 166 Phosphoserine (By similarity).
 MOD_RES 167 167 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 176 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003712; F:transcription cofactor activity; IEA:InterPro.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR003958; CBFA_NFYB_domain.
 IPR027113; Dr1/Ncb2.
 IPR009072; Histone-fold.
 IPR003957; Transcrpt_fac_CBFA/NFYB_topo. 

Pfam

 PF00808; CBFD_NFYB_HMF 

SMART

  

PROSITE

  

PRINTS

 PR00615; CCAATSUBUNTA.