UniProt Accession

 GBRL1_CAVPO; P60518; Q9JJ97 

Genbank Protein ID

 AF012920; AF312680 

Genbank Nucleotide ID

 AAL32264.1; AAK28484.1 

Protein Name

 Gamma-aminobutyric acid receptor-associated protein-like 1 

Protein Synonyms/Alias

 GABA(A) receptor-associated protein-like 1; Glandular epithelial cell protein 1; GEC-1 

Gene Name

 GABARAPL1 

Gene Synonyms/Alias

 GEC1 

Created Date

 July 27, 2013 

Organism

 Cavia porcellus (Guinea pig) 

NCBI Taxa ID

 10141 

Lysine Modification

Position	Peptide	Type	References
23	KEGEKIRKKYPDRVP	ubiquitination	[1]
24	EGEKIRKKYPDRVPV	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). 

Sequence Annotation

 REGION 1 22 Interaction with beta-tubulin (By
 REGION 36 68 Interaction with GABRG2 (By similarity).
 LIPID 116 116 Phosphatidylethanolamine amidated glycine  

Keyword

 Autophagy; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Endoplasmic reticulum; Golgi apparatus; Lipoprotein; Membrane; Microtubule; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 117 AA 

Protein Sequence

Gene Ontology

 GO:0005776; C:autophagic vacuole; IEA:UniProtKB-SubCell.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW. 

Interpro

 IPR004241; Atg8_ubiquitin-like. 

Pfam

 PF02991; Atg8 

SMART

  

PROSITE

  

PRINTS