UniProt Accession

 AQP4_MOUSE; P55088; P97818; Q4FJP1; Q61131; Q61132; Q8VHE4; Q8VHE5; Q9EQI3 

Genbank Protein ID

 U48398; U48397; U33012; U48400; U48399; U88623; AF469168; AF469169; AF219992; CT010362; BC024526 

Genbank Nucleotide ID

 AAB41569.1; AAB41568.1; AAA84923.1; AAB41571.1; AAB41570.1; AAC53155.1; AAL73545.1; AAL73546.1; AAG44243.2; CAJ18569.1; AAH24526.1 

Protein Name

 Aquaporin-4 

Protein Synonyms/Alias

 AQP-4; Mercurial-insensitive water channel; MIWC; WCH4 

Gene Name

 Aqp4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
268	RLKEAFSKAAQQTKG	ubiquitination	[1]
274	SKAAQQTKGSYMEVE	ubiquitination	[1]
295	ETEDLILKPGVVHVI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. 

Sequence Annotation

 MOTIF 97 99 NPA 1.
 MOTIF 213 215 NPA 2.
 MOD_RES 111 111 Phosphoserine; by PKG (By similarity).
 MOD_RES 180 180 Phosphoserine; by PKC (By similarity).
 MOD_RES 285 285 Phosphoserine (By similarity).
 MOD_RES 321 321 Phosphoserine (By similarity).
 CARBOHYD 153 153 N-linked (GlcNAc...) (Potential).
 CARBOHYD 206 206 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 323 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0005911; C:cell-cell junction; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:MGI.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0030315; C:T-tubule; IEA:Compara.
 GO:0015288; F:porin activity; IEA:Compara.
 GO:0015250; F:water channel activity; IDA:UniProtKB.
 GO:0015670; P:carbon dioxide transport; IEA:Compara.
 GO:0071392; P:cellular response to estradiol stimulus; IEA:Compara.
 GO:0071346; P:cellular response to interferon-gamma; IEA:Compara.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0042538; P:hyperosmotic salinity response; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0070295; P:renal water absorption; IMP:MGI.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0009314; P:response to radiation; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IMP:MGI. 

Interpro

 IPR023271; Aquaporin-like.
 IPR000425; MIP.
 IPR022357; MIP_CS. 

Pfam

 PF00230; MIP 

SMART

  

PROSITE

 PS00221; MIP 

PRINTS

 PR00783; MINTRINSICP.