CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021169
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neurensin-2 
Protein Synonyms/Alias
  
Gene Name
 NRSN2 
Gene Synonyms/Alias
 C20orf98 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
21GPSVEDGKWYGVRSYubiquitination[1, 2, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 May play a role in maintenance and/or transport of vesicles. 
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 204 AA 
Protein Sequence
MMPSCNRSCS CSRGPSVEDG KWYGVRSYLH LFYEDCAGTA LSDDPEGPPV LCPRRPWPSL 60
CWKISLSSGT LLLLLGVAAL TTGYAVPPKL EGIGEGEFLV LDQRAADYNQ ALGTCRLAGT 120
ALCVAAGVLL AICLFWAMIG WLSQDTKAEP LDPEADSHVE VFGDEPEQQL SPIFRNASGQ 180
SWFSPPASPF GQSSVQTIQP KRDS 204 
Gene Ontology
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:LIFEdb.
 GO:0030133; C:transport vesicle; ISS:UniProtKB. 
Interpro
 IPR024883; Neurensin. 
Pfam
  
SMART
  
PROSITE
  
PRINTS