CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005213
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear transcription factor Y subunit alpha 
Protein Synonyms/Alias
 CAAT box DNA-binding protein subunit A; Nuclear transcription factor Y subunit A; NF-YA 
Gene Name
 Nfya 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
283KRRQARAKLEAEGKIacetylation[1]
289AKLEAEGKIPKERRKacetylation[1]
Reference
 [1] Posttranslational regulation of NF-YA modulates NF-Y transcriptional activity.
 Manni I, Caretti G, Artuso S, Gurtner A, Emiliozzi V, Sacchi A, Mantovani R, Piaggio G.
 Mol Biol Cell. 2008 Dec;19(12):5203-13. [PMID: 18815279] 
Functional Description
 Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes. 
Sequence Annotation
 DNA_BIND 295 320 NFYA/HAP2-type.
 MOTIF 265 288 Subunit association domain (SAD).
 MOD_RES 325 325 Phosphoserine (By similarity).  
Keyword
 Activator; Alternative splicing; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 346 AA 
Protein Sequence
MEQYTTNSNS STEQIVVQAG QIQQQQGGVT AVQLQTEAQV ASASGQQVQT LQVVQGQPLM 60
VQVSGGQLIT STGQPIMVQA VPGGQGQTIM QVPVSGTQGL QQIQLVPPGQ IQIQGGQAVQ 120
VQGQQGQTQQ IIIQQPQTAV TAGQTQTQQQ IAVQGQQVAQ TAEGQTIVYQ PVNADGTILQ 180
QVTVPVSGMI TIPAASLAGA QIVQTGANTN TTSSGQGTVT VTLPVAGNVV NSGGMVMMVP 240
GAGSVPAIQR IPLPGAEMLE EEPLYVNAKQ YHRILKRRQA RAKLEAEGKI PKERRKYLHE 300
SRHRHAMARK RGEGGRFFSP KEKDSPHMQD PNQADEEAMT QIIRVS 346 
Gene Ontology
 GO:0016602; C:CCAAT-binding factor complex; IEA:InterPro.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR018362; CCAAT-binding_factor_CS.
 IPR001289; TF_CBFB. 
Pfam
 PF02045; CBFB_NFYA 
SMART
 SM00521; CBF 
PROSITE
 PS00686; NFYA_HAP2_1
 PS51152; NFYA_HAP2_2 
PRINTS
 PR00616; CCAATSUBUNTB.