UniProt Accession

 APA1_YEAST; P16550; D6VQW6 

Genbank Protein ID

 M35204; M31791; X59720; BK006937 

Genbank Nucleotide ID

 AAA34581.1; AAA34427.1; CAA42394.2; DAA07435.1 

Protein Name

 Protein APA1 

Protein Synonyms/Alias

 5',5'''-P-1,P-4-tetraphosphate phosphorylase; ATP adenylyltransferase; Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase; AP,A phosphorylase; AP-4-A phosphorylase; ADP-sulfurylase 

Gene Name

 APA1 

Gene Synonyms/Alias

 DTP1; YCL050C; YCL50C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
25	AFDNGNLKFIQTETT	acetylation	[1]
54	HMPSLIEKPERGQTP	acetylation	[1]
138	LDNEESDKRHMVFYN	ubiquitination	[2]
167	QILQMPEKFVTFQDR	ubiquitination	[2]
284	YCGMILTKNDEVFSK	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Ap4A phosphorylase catabolizes Ap4N nucleotides (where N is A,C,G or U). Additionally this enzyme catalyzes the conversion of adenosine-5-phosphosulfate (AMPs) plus Pi to ADP plus sulfate, the exchange of NDP and phosphate and the synthesis of Ap4A from AMPs plus ATP. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (Probable).
 MOD_RES 60 60 Phosphothreonine.  

Keyword

 Acetylation; ATP-binding; Complete proteome; Direct protein sequencing; Hydrolase; Nucleotide-binding; Nucleotidyltransferase; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 321 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0003877; F:ATP adenylyltransferase activity; IEA:EC.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008796; F:bis(5'-nucleosyl)-tetraphosphatase activity; IDA:SGD.
 GO:0004780; F:sulfate adenylyltransferase (ADP) activity; IDA:SGD.
 GO:0009164; P:nucleoside catabolic process; IDA:SGD.
 GO:0009165; P:nucleotide biosynthetic process; IDA:SGD. 

Interpro

 IPR009163; ATP_adenylyltransferase.
 IPR019200; ATP_adenylylTrfase_C.
 IPR011146; HIT-like. 

Pfam

 PF09830; ATP_transf 

SMART

  

PROSITE

  

PRINTS