CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040382
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase MIB1 
Protein Synonyms/Alias
  
Gene Name
 Mib1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
56RLSQLLKKLFETQESubiquitination[1]
120DILKLLLKQNVDVEAubiquitination[1]
361QDMQDVGKVDAAWEPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 641 AA 
Protein Sequence
XGKVGRVQQI YSDSDLKVEV CGTSWTYNPA AVSKVAPAGS AISNASGERL SQLLKKLFET 60
QESGDLNEEL VKAAANGDVA KVEDLLKRPD VDVNGQCAGH TAMQAASQNG HVDILKLLLK 120
QNVDVEAEDK DGDRAVHHAA FGDEGAVIEV LHRGSADLNA RNKRRQTPLH IAVNKGHLQV 180
VKTLLDFGCH PSLQDSEGDT PLHDAISKKR DDILAVLLEA GADVTITNNN GFNALHHAAL 240
RGNPSAMRVL LSKLPRPWIV DEKKDDGYTA LHLAALNNHV EVAELLVHQG NANLDIQNVN 300
QQTALHLAVE RQHTQIVRLL VRAGAKLDIQ DKDGDTPLHE ALRHHTLSQL RQLQDMQDVG 360
KVDAAWEPSK NTLIMGLGTQ GAEKKSAASI ACFLAANGAD LSIRNKKGQS PLDLCPDPSL 420
CKALAKCHKE KVSGQVGSRS PSMISNDSET LEECMVCSDM KRDTLFGPCG HIATCSLCSP 480
RVKKCLICKE QVQSRTKIEE CVVCSDKKAA VLFQPCGHMC ACENCASLMK KCVQCRAVVE 540
RRVPFITCCG GKSSEDPSDE ISSGNIPVLQ KDKDNTNVNA DVQKLQQQLQ DIKEQTMCPV 600
CLDRLKNMIF LCGHGTCQLC GDRMSECPIC RKAIERRILL Y 641 
Gene Ontology
 GO:0031410; C:cytoplasmic vesicle; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0001568; P:blood vessel development; IMP:MGI.
 GO:0001947; P:heart looping; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0045665; P:negative regulation of neuron differentiation; IMP:MGI.
 GO:0001841; P:neural tube formation; IMP:MGI.
 GO:0007219; P:Notch signaling pathway; IMP:MGI.
 GO:0045807; P:positive regulation of endocytosis; IDA:MGI.
 GO:0001756; P:somitogenesis; IMP:MGI. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00023; Ank
 PF12796; Ank_2 
SMART
 SM00248; ANK
 SM00184; RING 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50089; ZF_RING_2 
PRINTS
 PR01415; ANKYRIN.