UniProt Accession

 UK114_HUMAN; P52758; Q6FHU9; Q6IBG0 

Genbank Protein ID

 X95384; AY026764; CR456844; CR541652; CH471060; BC010280; BC012592; BC093059 

Genbank Nucleotide ID

 CAA64670.1; AAK01939.1; CAG33125.1; CAG46453.1; EAW91774.1; AAH10280.1; AAH12592.1; AAH93059.1 

Protein Name

 Ribonuclease UK114 

Protein Synonyms/Alias

 14.5 kDa translational inhibitor protein; p14.5; Heat-responsive protein 12; UK114 antigen homolog 

Gene Name

 HRSP12 

Gene Synonyms/Alias

 PSP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
13	RRVISTAKAPGAIGP	ubiquitination	[1]
101	EIYKQYFKSNFPARA	acetylation	[2]

Reference

 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 21 21 Phosphotyrosine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Endonuclease; Hydrolase; Nuclease; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 137 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0019239; F:deaminase activity; IEA:InterPro.
 GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0006449; P:regulation of translational termination; TAS:ProtInc. 

Interpro

 IPR013813; Endoribo_LPSP/chorism_mut-like.
 IPR006056; YjgF-like.
 IPR019897; YjgF-like_CS.
 IPR006175; YjgF/Yer057p/UK114. 

Pfam

 PF01042; Ribonuc_L-PSP 

SMART

  

PROSITE

 PS01094; UPF0076 

PRINTS