CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012097
UniProt Accession
Genbank Protein ID
 U41315 
Genbank Nucleotide ID
Protein Name
 Putative E3 ubiquitin-protein ligase makorin-4 
Protein Synonyms/Alias
 Makorin RING finger protein pseudogene 4; Makorin RING finger protein pseudogene 5; RING finger protein 64; Zinc finger protein 127-Xp; ZNF127-Xp; Zinc finger protein 127-like 1 
Gene Name
 MKRN4P 
Gene Synonyms/Alias
 MKRN4; MKRNP5; RNF64; ZNF127L1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
386SEYWVEEKEEKQKLIubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). 
Sequence Annotation
 ZN_FING 90 117 C3H1-type 1.
 ZN_FING 124 146 C3H1-type 2.
 ZN_FING 243 270 C3H1-type 3.
 ZN_FING 316 370 RING-type.
 ZN_FING 399 428 C3H1-type 4.
 REGION 271 298 Makorin-type Cys-His.  
Keyword
 Complete proteome; Ligase; Metal-binding; Reference proteome; Repeat; Ubl conjugation pathway; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 485 AA 
Protein Sequence
MAEAAAPGTT VTTSGAGAAA AEAAETAEAV SPTPIPTVTA PSPRAGGGVG GSDGSDGSGG 60
RGDSGAYDGS GACGGSDACD GSGDSSGDSW TKQVTCRYFK YGICKEGDNC RYSHDLSDRL 120
CGVVCKYFQR GCCVYGDRCR CEHSKPLKQE EATATELTTK SSLAASSSLS SIVGPLVEMN 180
TNEAESRNSN FATVVAGSED WANAIEFVPG QPYCGRTVPS CTEAPLQGSV TKEESEEEQT 240
AVETKKQLCP YAAVGQCRYG ENCVYLHGDL CDMCGLQVLH PMDAAQRSQH IQACIEAHEK 300
DMEFSFAVQR SKDKVCGICM EVVYEKANPN EHRFGILSNC NHTFCLKCIR KWRSAKEFES 360
RIVKSCPQCR ITSNFVIPSE YWVEEKEEKQ KLIQKYKEAM SNKACKYFDE GRGSCPFGEN 420
CFYKHMYPDG RREEPQRQQV GTSSRNPGQQ RNHFWEFFEE GANSNPFDDE EEAVTFELGE 480
MLLML 485 
Gene Ontology
 GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. 
Interpro
 IPR026290; Makorin-related.
 IPR000571; Znf_CCCH.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00642; zf-CCCH
 PF13639; zf-RING_2 
SMART
 SM00184; RING
 SM00356; ZnF_C3H1 
PROSITE
 PS50103; ZF_C3H1
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS