| Tag | Content |
|---|
| CPLM ID | CPLM-014049 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CTP synthase 2 |
Protein Synonyms/Alias | CTP synthetase 2; UTP--ammonia ligase 2 |
Gene Name | Ctps2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 100 | IYQHVINKERRGDYL | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). |
Sequence Annotation | DOMAIN 300 554 Glutamine amidotransferase type-1.
ACT_SITE 399 399 For GATase activity (By similarity).
ACT_SITE 526 526 For GATase activity (By similarity).
ACT_SITE 528 528 For GATase activity (By similarity).
MOD_RES 568 568 Phosphoserine (By similarity).
MOD_RES 571 571 Phosphoserine (By similarity).
MOD_RES 574 574 Phosphoserine (By similarity). |
Keyword | ATP-binding; Complete proteome; Glutamine amidotransferase; Ligase; Nucleotide-binding; Phosphoprotein; Pyrimidine biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 586 AA |
Protein Sequence | MKYILVTGGV ISGIGKGIIA SSIGTILKSC GLRVTAIKID PYINIDAGTF SPYEHGEVFV 60
LNDGGEVDLD LGNYERFLDI NLYKDNNITT GKIYQHVINK ERRGDYLGKT VQVVPHITDA 120
IQDWVMNQAK VSVDGNKEDP QICVIELGGT IGDIEGMAFV EAFRQFQFKA KRENFYNIHV 180
SLVPQPSATG EQKTKPTQNS VRALRGLGLS PDLIVCRSST PIEMAVKEKI SMFCHVNPEQ 240
VICIHDVSSI YRVPLLLEEQ GVVKYFQERL DLPINDCSNN LLFKWKTMAD RYERLQKICS 300
IALVGKYTKL RDCYASVFKA LEHSALAINH KLNLMYIDSI DLEPVTKAED PVKFHEAWQK 360
LCLADGILVP GGFGIRGTLG KLQAISWART KKIPFLGICL GMQLAVIEFA RNCLNLKDAN 420
STEFDPNTPV PLVIDMPEHN PGDLGGTMRL GLRRTVFTTE NSILKKLYGD VPYIEERHRH 480
RYEVNPNLIN QFENKDLCFV GEDVDGKRME IIELTGHPYF IGVQFHPEFS SRPMKPSPPY 540
LGLLLAATGT LNTHLQQMSK LSYSDIYSDA SDDSFSEAKF AELDIN 586 |
Gene Ontology | GO:0005739; C:mitochondrion; IEA:Compara. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0003883; F:CTP synthase activity; IEA:EC. GO:0044210; P:'de novo' CTP biosynthetic process; IEA:UniProtKB-UniPathway. GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |