| Tag | Content |
|---|
| CPLM ID | CPLM-018883 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Glutaryl-CoA dehydrogenase, mitochondrial |
Protein Synonyms/Alias | GCD |
Gene Name | GCDH |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 32 | SSAAQTEKGGRTQSQ | ubiquitination | [1] | | 163 | GSEEQRQKYLPQLAK | ubiquitination | [1] | | 202 | AHYNSSNKSYTLNGT | ubiquitination | [1] | | 240 | IRGFLLEKGMRGLSA | ubiquitination | [1] | | 371 | PEMVSLLKRNNCGKA | ubiquitination | [1] | | 377 | LKRNNCGKALDIARQ | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive. |
Sequence Annotation | NP_BIND 177 186 FAD.
NP_BIND 212 214 FAD.
NP_BIND 387 391 FAD (By similarity).
NP_BIND 416 418 FAD.
REGION 138 139 Substrate binding.
REGION 287 294 Substrate binding.
ACT_SITE 414 414 Proton acceptor (Probable).
BINDING 186 186 Substrate; via carbonyl oxygen.
BINDING 319 319 FAD (By similarity).
BINDING 330 330 FAD (By similarity).
BINDING 415 415 Substrate; via amide nitrogen.
BINDING 434 434 FAD; via carbonyl oxygen. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Disease mutation; FAD; Flavoprotein; Glutaricaciduria; Mitochondrion; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 438 AA |
Protein Sequence | MALRGVSVRL LSRGPGLHVL RTWVSSAAQT EKGGRTQSQL AKSSRPEFDW QDPLVLEEQL 60
TTDEILIRDT FRTYCQERLM PRILLANRNE VFHREIISEM GELGVLGPTI KGYGCAGVSS 120
VAYGLLAREL ERVDSGYRSA MSVQSSLVMH PIYAYGSEEQ RQKYLPQLAK GELLGCFGLT 180
EPNSGSDPSS METRAHYNSS NKSYTLNGTK TWITNSPMAD LFVVWARCED GCIRGFLLEK 240
GMRGLSAPRI QGKFSLRASA TGMIIMDGVE VPEENVLPGA SSLGGPFGCL NNARYGIAWG 300
VLGASEFCLH TARQYALDRM QFGVPLARNQ LIQKKLADML TEITLGLHAC LQLGRLKDQD 360
KAAPEMVSLL KRNNCGKALD IARQARDMLG GNGISDEYHV IRHAMNLEAV NTYEGTHDIH 420
ALILGRAITG IQAFTASK 438 |
Gene Ontology | GO:0005743; C:mitochondrial inner membrane; IEA:Compara. GO:0005759; C:mitochondrial matrix; TAS:Reactome. GO:0000062; F:fatty-acyl-CoA binding; IEA:Compara. GO:0050660; F:flavin adenine dinucleotide binding; IEA:Compara. GO:0004361; F:glutaryl-CoA dehydrogenase activity; EXP:Reactome. GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome. GO:0019395; P:fatty acid oxidation; IEA:Compara. GO:0046949; P:fatty-acyl-CoA biosynthetic process; IEA:Compara. GO:0006554; P:lysine catabolic process; TAS:Reactome. GO:0006568; P:tryptophan metabolic process; IEA:UniProtKB-UniPathway. |
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Pfam | |
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PRINTS | |