UniProt Accession

 2ABA_RAT; P36876; A1A5M9; O35512; P36878 

Genbank Protein ID

 M83298; M83297; BC128731; D14419 

Genbank Nucleotide ID

 AAA41910.1; AAA41909.1; AAI28732.1; BAA21904.1 

Protein Name

 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform 

Protein Synonyms/Alias

 PP2A subunit B isoform B55-alpha; PP2A subunit B isoform BRA; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform R2-alpha; PP2A subunit B isoform alpha 

Gene Name

 Ppp2r2a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
98	EIEEKINKIRWLPQK	acetylation	[1]
105	KIRWLPQKNAAQFLL	ubiquitination	[2, 3]
393	NKPRTVLKPRKVCAS	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. 

Sequence Annotation

 REPEAT 26 65 WD 1.
 REPEAT 91 132 WD 2.
 REPEAT 175 213 WD 3.
 REPEAT 224 264 WD 4.
 REPEAT 283 321 WD 5.
 REPEAT 338 379 WD 6.
 REPEAT 414 446 WD 7.
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Complete proteome; Polymorphism; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 447 AA 

Protein Sequence

Gene Ontology

 GO:0000159; C:protein phosphatase type 2A complex; IEA:InterPro.
 GO:0008601; F:protein phosphatase type 2A regulator activity; IEA:InterPro.
 GO:0004722; F:protein serine/threonine phosphatase activity; IEA:Compara.
 GO:0006470; P:protein dephosphorylation; IEA:Compara.
 GO:0043278; P:response to morphine; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR000009; PP2A_PR55.
 IPR018067; PP2A_PR55_CS.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

  

SMART

 SM00320; WD40 

PROSITE

 PS01024; PR55_1
 PS01025; PR55_2
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00600; PP2APR55.