| Tag | Content |
|---|
| CPLM ID | CPLM-019482 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dedicator of cytokinesis protein 7 |
Protein Synonyms/Alias | |
Gene Name | DOCK7 |
Gene Synonyms/Alias | KIAA1771 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 922 | VRSIIGSKAMDRSCN | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. |
Sequence Annotation | DOMAIN 561 727 DHR-1.
DOMAIN 1678 2114 DHR-2.
MOD_RES 28 28 Phosphoserine.
MOD_RES 30 30 Phosphoserine.
MOD_RES 180 180 Phosphoserine.
MOD_RES 182 182 Phosphoserine.
MOD_RES 439 439 Phosphoserine (By similarity).
MOD_RES 440 440 Phosphoserine (By similarity).
MOD_RES 882 882 Phosphoserine.
MOD_RES 888 888 Phosphoserine.
MOD_RES 896 896 Phosphoserine.
MOD_RES 900 900 Phosphoserine.
MOD_RES 905 905 Phosphoserine.
MOD_RES 907 907 Phosphothreonine.
MOD_RES 909 909 Phosphothreonine.
MOD_RES 910 910 Phosphoserine.
MOD_RES 964 964 Phosphoserine (By similarity).
MOD_RES 966 966 Phosphothreonine (By similarity).
MOD_RES 1383 1383 Phosphoserine.
MOD_RES 1430 1430 Phosphoserine.
MOD_RES 1432 1432 Phosphoserine.
MOD_RES 1438 1438 Phosphoserine.
MOD_RES 1962 1962 N6-acetyllysine. |
Keyword | Acetylation; Alternative splicing; Cell projection; Coiled coil; Complete proteome; Developmental protein; Differentiation; Guanine-nucleotide releasing factor; Neurogenesis; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2140 AA |
Protein Sequence | MAERRAFAQK ISRTVAAEVR KQISGQYSGS PQLLKNLNIV GNISHHTTVP LTEAVDPVDL 60
EDYLITHPLA VDSGPLRDLI EFPPDDIEVV YSPRDCRTLV SAVPEESEMD PHVRDCIRSY 120
TEDWAIVIRK YHKLGTGFNP NTLDKQKERQ KGLPKQVFES DEAPDGNSYQ DDQDDLKRRS 180
MSIDDTPRGS WACSIFDLKN SLPDALLPNL LDRTPNEEID RQNDDQRKSN RHKELFALHP 240
SPDEEEPIER LSVPDIPKEH FGQRLLVKCL SLKFEIEIEP IFASLALYDV KEKKKISENF 300
YFDLNSEQMK GLLRPHVPPA AITTLARSAI FSITYPSQDV FLVIKLEKVL QQGDIGECAE 360
PYMIFKEADA TKNKEKLEKL KSQADQFCQR LGKYRMPFAW TAIHLMNIVS SAGSLERDST 420
EVEISTGERK GSWSERRNSS IVGRRSLERT TSGDDACNLT SFRPATLTVT NFFKQEGDRL 480
SDEDLYKFLA DMRRPSSVLR RLRPITAQLK IDISPAPENP HYCLTPELLQ VKLYPDSRVR 540
PTREILEFPA RDVYVPNTTY RNLLYIYPQS LNFANRQGSA RNITVKVQFM YGEDPSNAMP 600
VIFGKSSCSE FSKEAYTAVV YHNRSPDFHE EIKVKLPATL TDHHHLLFTF YHVSCQQKQN 660
TPLETPVGYT WIPMLQNGRL KTGQFCLPVS LEKPPQAYSV LSPEVPLPGM KWVDNHKGVF 720
NVEVVAVSSI HTQDPYLDKF FALVNALDEH LFPVRIGDMR IMENNLENEL KSSISALNSS 780
QLEPVVRFLH LLLDKLILLV IRPPVIAGQI VNLGQASFEA MASIINRLHK NLEGNHDQHG 840
RNSLLASYIH YVFRLPNTYP NSSSPGPGGL GGSVHYATMA RSAVRPASLN LNRSRSLSNS 900
NPDISGTPTS PDDEVRSIIG SKAMDRSCNR MSSHTETSSF LQTLTGRLPT KKLFHEELAL 960
QWVVCSGSVR ESALQQAWFF FELMVKSMVH HLYFNDKLEA PRKSRFPERF MDDIAALVST 1020
IASDIVSRFQ KDTEMVERLN TSLAFFLNDL LSVMDRGFVF SLIKSCYKQV SSKLYSLPNP 1080
SVLVSLRLDF LRIICSHEHY VTLNLPCSLL TPPASPSPSV SSATSQSSGF STNVQDQKIA 1140
NMFELSVPFR QQHYLAGLVL TELAVILDPD AEGLFGLHKK VINMVHNLLS SHDSDPRYSD 1200
PQIKARVAML YLPLIGIIME TVPQLYDFTE THNQRGRPIC IATDDYESES GSMISQTVAM 1260
AIAGTSVPQL TRPGSFLLTS TSGRQHTTFS AESSRSLLIC LLWVLKNADE TVLQKWFTDL 1320
SVLQLNRLLD LLYLCVSCFE YKGKKVFERM NSLTFKKSKD MRAKLEEAIL GSIGARQEMV 1380
RRSRGQLERS PSGSAFGSQE NLRWRKDMTH WRQNTEKLDK SRAEIEHEAL IDGNLATEAN 1440
LIILDTLEIV VQTVSVTESK ESILGGVLKV LLHSMACNQS AVYLQHCFAT QRALVSKFPE 1500
LLFEEETEQC ADLCLRLLRH CSSSIGTIRS HASASLYLLM RQNFEIGNNF ARVKMQVTMS 1560
LSSLVGTSQN FNEEFLRRSL KTILTYAEED LELRETTFPD QVQDLVFNLH MILSDTVKMK 1620
EHQEDPEMLI DLMYRIAKGY QTSPDLRLTW LQNMAGKHSE RSNHAEAAQC LVHSAALVAE 1680
YLSMLEDRKY LPVGCVTFQN ISSNVLEESA VSDDVVSPDE EGICSGKYFT ESGLVGLLEQ 1740
AAASFSMAGM YEAVNEVYKV LIPIHEANRD AKKLSTIHGK LQEAFSKIVH QSTGWERMFG 1800
TYFRVGFYGT KFGDLDEQEF VYKEPAITKL AEISHRLEGF YGERFGEDVV EVIKDSNPVD 1860
KCKLDPNKAY IQITYVEPYF DTYEMKDRIT YFDKNYNLRR FMYCTPFTLD GRAHGELHEQ 1920
FKRKTILTTS HAFPYIKTRV NVTHKEEIIL TPIEVAIEDM QKKTQELAFA THQDPADPKM 1980
LQMVLQGSVG TTVNQGPLEV AQVFLSEIPS DPKLFRHHNK LRLCFKDFTK RCEDALRKNK 2040
SLIGPDQKEY QRELERNYHR LKEALQPLIN RKIPQLYKAV LPVTCHRDSF SRMSLRKMDL 2100 |
Gene Ontology | GO:0030424; C:axon; TAS:BHF-UCL. GO:0045178; C:basal part of cell; TAS:BHF-UCL. GO:0030426; C:growth cone; TAS:BHF-UCL. GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. GO:0048365; F:Rac GTPase binding; IDA:BHF-UCL. GO:0032863; P:activation of Rac GTPase activity; IDA:BHF-UCL. GO:0007409; P:axonogenesis; IMP:BHF-UCL. GO:0045200; P:establishment of neuroblast polarity; IMP:BHF-UCL. GO:0000226; P:microtubule cytoskeleton organization; IMP:BHF-UCL. GO:0043473; P:pigmentation; IEA:Compara. GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:BHF-UCL. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |