| Tag | Content |
|---|
| CPLM ID | CPLM-021119 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin conjugation factor E4 B |
Protein Synonyms/Alias | Ubiquitin fusion degradation protein 2; Ufd2a |
Gene Name | Ube4b |
Gene Synonyms/Alias | Ufd2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1040 | LDCARFAKAIADDQR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3 (By similarity). |
Sequence Annotation | DOMAIN 1102 1164 U-box.
MOD_RES 31 31 Phosphoserine.
MOD_RES 84 84 Phosphoserine (By similarity).
MOD_RES 88 88 Phosphoserine (By similarity).
MOD_RES 90 90 Phosphoserine (By similarity).
MOD_RES 101 101 Phosphoserine.
MOD_RES 103 103 Phosphoserine (By similarity).
MOD_RES 105 105 Phosphoserine.
MOD_RES 674 674 Phosphoserine (By similarity).
MOD_RES 1136 1136 Phosphoserine (By similarity). |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1173 AA |
Protein Sequence | MEELSADEIR RRRLARLAGG QTSQPTTPLT SPQRENPPGP PIAASAPGPS QSLGLNVHNM 60
TPATSPIGAA GVAHRSQSSE GVSSLSSSPS NSLETQSQSL SRSQSMDIDG VSCEKSMSQV 120
DVDSGIENME VDENDRREKR SLSDKEPSSG PEVSEEQALQ LVCKIFRVSW KDRDRDVIFL 180
SSLSAQFKQN PKEVFSDFKD LIGQILMEVL MMSTQTRDEN PFASLTATSQ PIATAARSPD 240
RNLMLNTGSS SGTSPMFCNM GSFSTSSLSS LGASGGASNW DSYSDHFTIE TCKETDMLNY 300
LIECFDRVGI EEKKAPKMCS QPAVSQLLSN IRSQCISHTA LVLQGSLTQP RSLQQPSFLV 360
PYMLCRNLPY GFIQELVRTT HQDEEVFKQI FIPILQGLAL AAKECSLESD YFKYPLMALG 420
ELCETKFGKT HPMCNLVASL PLWLPKSLSP GSGRELQRLS YLGAFFSFSV FAEDDAKVVE 480
KYFSGPAITL ENTRVVSQSL QHYLELGRQE LFKILHSILL NGETREAALS YMAALVNANM 540
KKAQMQADDR LVSTDGFMLN LLWVLQQLST KIKLETVDPT YIFHPRCRIT LPNDETRINA 600
TMEDVNERLT ELYGDQPPFS EPKFPTECFF LTLHAHHLSI LPSCRRYIRR LRAIRELNRT 660
VEDLKNNESQ WKDSPLATRH REMLKRCKTQ LKKLVRCKAC ADAGLLDESF LRRCLNFYGL 720
LIQLMLRILD PAYPDVTLPL NSEVPKVFAA LPEFYVEDVA EFLFFIVQYS PQVLYEPCTQ 780
DIVMFLVVML CNQNYIRNPY LVAKLVEVMF MTNPSVQPRT QKFFEMIENH PLSTKLLVPS 840
LMKFYTDVEH TGATSEFYDK FTIRYHISTI FKSLWQNIAH HGTFMEEFNS GKQFVRYINM 900
LINDTTFLLD ESLESLKRIH EVQEEMKNKE QWDQLPRDQQ QARQSQLAQD ERVSRSYLAL 960
ATETVDMFHL LTKQVQKPFL RPELGPRLAA MLNFNLQQLC GPKCRDLKVE NPEKYGFEPK 1020
KLLDQLTDIY LQLDCARFAK AIADDQRSYS KELFEEVISK MRKAGIKSTI AIEKFKLLAE 1080
KVEEIVAKNA RAEIDYSDAP DEFRDPLMDT LMTDPVRLPS GTVMDRSIIL RHLLNSPTDP 1140
FNRQMLTESM LEPVPELKEQ IQAWMREKQS SDH 1173 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0000151; C:ubiquitin ligase complex; TAS:UniProtKB. GO:0034450; F:ubiquitin-ubiquitin ligase activity; IEA:InterPro. GO:0051082; F:unfolded protein binding; NAS:UniProtKB. GO:0008626; P:granzyme-mediated apoptotic signaling pathway; ISS:UniProtKB. GO:0006457; P:protein folding; NAS:UniProtKB. GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; TAS:UniProtKB. GO:0009411; P:response to UV; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |