CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032073
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isobutyryl-CoA dehydrogenase, mitochondrial 
Protein Synonyms/Alias
 cDNA FLJ55244, highly similar to Acyl-CoA dehydrogenase family member 8, mitochondrial (EC 1.3.99.-) 
Gene Name
 ACAD8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
67GNEEQRHKFCPPLCTubiquitination[1]
100ASLLTSAKKQGDHYIubiquitination[1]
101SLLTSAKKQGDHYILubiquitination[1]
136RTGGPGPKGISCIVVubiquitination[1]
155PGLSFGKKEKKVGWNubiquitination[1]
158SFGKKEKKVGWNSQPubiquitination[1]
226RDHLNVRKQFGEPLAubiquitination[1]
268VALQEERKDAVALCSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; FAD; Flavoprotein; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 357 AA 
Protein Sequence
MRKAAQLGFG GVYIQTDVGG SGLSRLDTSV IFEALATGCT STTAYISIHN MCAWMIDSFG 60
NEEQRHKFCP PLCTMEKFAS YCLTEPGSGS DAASLLTSAK KQGDHYILNG SKAFISGAGE 120
SDIYVVMCRT GGPGPKGISC IVVEKGTPGL SFGKKEKKVG WNSQPTRAVI FEDCAVPVAN 180
RIGSEGQGFL IAVRGLNGGR INIASCSLGA AHASVILTRD HLNVRKQFGE PLASNQYLQF 240
TLADMATRLV AARLMVRNAA VALQEERKDA VALCSMAKLF ATDECFAICN QALQMHGGYG 300
YLKDYAVQQY VRDSRVHQIL EELFWQGPGV QSRSFVPFGG PQIALLLPFS SGDLREG 357 
Gene Ontology
 GO:0003995; F:acyl-CoA dehydrogenase activity; IEA:InterPro.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. 
Interpro
 IPR006089; Acyl-CoA_DH_CS.
 IPR006092; Acyl-CoA_DH_N.
 IPR006090; Acyl-CoA_Oxase/DH_1.
 IPR006091; Acyl-CoA_Oxase/DH_cen-dom.
 IPR009075; AcylCo_DH/oxidase_C.
 IPR013786; AcylCoA_DH/ox_N.
 IPR009100; AcylCoA_DH/oxidase. 
Pfam
 PF00441; Acyl-CoA_dh_1
 PF02770; Acyl-CoA_dh_M
 PF02771; Acyl-CoA_dh_N 
SMART
  
PROSITE
 PS00072; ACYL_COA_DH_1 
PRINTS