CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042139
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dihydrolipoyl dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 LOC100721798 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Cavia porcellus (Guinea pig) 
NCBI Taxa ID
 10141 
Lysine Modification
Position
Peptide
Type
References
66KAAQLGFKTVCVEKNacetylation[1]
104YYHMAHGKDFASRGIacetylation[1]
122EVRLNLEKMMEQKTNacetylation[1]
132EQKTNAVKALTGGIAacetylation[1]
143GGIAHLFKQNKVVHVacetylation[1]
146AHLFKQNKVVHVNGFacetylation[1]
155VHVNGFGKITGKNQVacetylation[1]
166KNQVTATKADGGTQVacetylation[1]
267NFQRILQKQGFKFKLacetylation[1]
271ILQKQGFKFKLNTKVacetylation[1]
273QKQGFKFKLNTKVTGacetylation[1]
277FKFKLNTKVTGATKKacetylation[1]
346VNSRFQTKVPNIYAIacetylation[1]
410GKSEEQLKEEGIEYKacetylation[1]
420GIEYKVGKFPFAANSacetylation[1]
Reference
 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; FAD; Flavoprotein; NAD; Oxidoreductase; Redox-active center; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 509 AA 
Protein Sequence
MQSWSRVYRS LAKRGHFNRI SHGLQGVSAV PLRTYADQSI DADVTVVGSG PGGYVAAIKA 60
AQLGFKTVCV EKNETLGGTC LNVGCIPSKA LLNNSHYYHM AHGKDFASRG IEMSEVRLNL 120
EKMMEQKTNA VKALTGGIAH LFKQNKVVHV NGFGKITGKN QVTATKADGG TQVIDTKNIL 180
IATGSEVTPF PGITIDEDTI VSSTGALSLK KVPEKMVVIG AGVIGVELGS VWQRLGADVT 240
AVEFLGHVGG VGIDMEISKN FQRILQKQGF KFKLNTKVTG ATKKSDGKID VSIEAASGGK 300
AEVITCDVLL VCIGRRPFTQ NLGLEELGIE LDPRGRIPVN SRFQTKVPNI YAIGDVVAGP 360
MLAHKAEDEG IICVEGMAGG AVHIDYNCVP SVIYTHPEVA WVGKSEEQLK EEGIEYKVGK 420
FPFAANSRAK TNADTDGMVK IIGQKATDRV LGAHILGPGA GEMVNEAALA LEYGASCEDI 480
ARVCHAHPTL SEAFREANLA ASFGKAINF 509 
Gene Ontology
 GO:0043159; C:acrosomal matrix; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004148; F:dihydrolipoyl dehydrogenase activity; IEA:EC.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0007369; P:gastrulation; IEA:Compara.
 GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:Compara.
 GO:0006508; P:proteolysis; IEA:Compara.
 GO:0042391; P:regulation of membrane potential; IEA:Compara.
 GO:0048240; P:sperm capacitation; IEA:Compara. 
Interpro
 IPR016156; FAD/NAD-linked_Rdtase_dimer.
 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR006258; Lipoamide_DH.
 IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
 IPR012999; Pyr_OxRdtase_I_AS.
 IPR001327; Pyr_OxRdtase_NAD-bd_dom. 
Pfam
 PF00070; Pyr_redox
 PF07992; Pyr_redox_2
 PF02852; Pyr_redox_dim 
SMART
  
PROSITE
 PS00076; PYRIDINE_REDOX_1 
PRINTS
 PR00368; FADPNR.