UniProt Accession

 ACOT9_MOUSE; Q9R0X4; Q545G7; Q9WTJ0; Q9WUZ8 

Genbank Protein ID

 AJ238893; AB028898; AK002892; AK009717; AK168713; AK170876; BX005263; BX119978; BX119978; BX005263; BC021763 

Genbank Nucleotide ID

 CAB45192.1; BAA79193.1; BAB22437.1; BAB26460.1; BAE40555.1; BAE42086.1; CAM23138.1; CAM23138.1; CAM21953.1; CAM21953.1; AAH21763.1 

Protein Name

 Acyl-coenzyme A thioesterase 9, mitochondrial 

Protein Synonyms/Alias

 Acyl-CoA thioesterase 9; Acyl coenzyme A thioester hydrolase 2; MTE-2; Acyl-CoA thioester hydrolase 9; Mitochondrial 48 kDa acyl-CoA thioester hydrolase 1; Mt-ACT48.1; Protein U8; p48 

Gene Name

 Acot9 

Gene Synonyms/Alias

 Acate2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
102	TDPELRDKYVTVQNT	acetylation	[1]
231	KEEEELFKQGELNKS	acetylation	[2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs. 

Sequence Annotation

 MOD_RES 102 102 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Hydrolase; Mitochondrion; Reference proteome; Serine esterase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 439 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:HGNC.
 GO:0003986; F:acetyl-CoA hydrolase activity; IDA:HGNC.
 GO:0047617; F:acyl-CoA hydrolase activity; IDA:MGI.
 GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW.
 GO:0006637; P:acyl-CoA metabolic process; IDA:HGNC. 

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