CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021967
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ubinuclein-1 
Protein Synonyms/Alias
 HIRA-binding protein; Protein VT4; Ubiquitously expressed nuclear protein 
Gene Name
 UBN1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
222SKKSKFSKAGFTALNacetylation[1, 2]
261KEKEAQKKREEEHKPacetylation[1]
267KKREEEHKPVAVPSAacetylation[2, 3, 4]
888SALSHPAKPHSVSSAacetylation[4]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly. 
Sequence Annotation
 REGION 1 166 Sufficient for interaction with HIRA.
 MOD_RES 173 173 Phosphoserine.
 MOD_RES 175 175 Phosphoserine.
 MOD_RES 222 222 N6-acetyllysine.
 MOD_RES 336 336 Phosphoserine.
 MOD_RES 338 338 Phosphoserine.
 MOD_RES 493 493 Phosphoserine.
 MOD_RES 660 660 Phosphoserine.
 MOD_RES 677 677 Phosphoserine.
 MOD_RES 1025 1025 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Cell junction; Chromatin regulator; Coiled coil; Complete proteome; DNA-binding; Host-virus interaction; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Tight junction. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1134 AA 
Protein Sequence
MSEPHRVQFT SLPGSLNPAF LKKSRKEEAG AGEQHQDCEP AAAAVRITLT LFEPDHKRCP 60
EFFYPELVKN IRGKVKGLQP GDKKKDLSDP FNDEEKERHK VEALARKFEE KYGGKKRRKD 120
RIQDLIDMGY GYDESDSFID NSEAYDELVP ASLTTKYGGF YINSGTLQFR QASESEDDFI 180
KEKKKKSPKK RKLKEGGEKI KKKKKDDTYD KEKKSKKSKF SKAGFTALNA SKEKKKKKYS 240
GALSVKEMLK KFQKEKEAQK KREEEHKPVA VPSAEAQGLR ELEGASDPLL SLFGSTSDND 300
LLQAATAMDS LTDLDLEHLL SESPEGSPFR DMDDGSDSLG VGLDQEFRQP SSLPEGLPAP 360
LEKRVKELAQ AARAAEGESR QKFFTQDING ILLDIEAQTR ELSSQVRSGV YAYLASFLPC 420
SKDALLKRAR KLHLYEQGGR LKEPLQKLKE AIGRAMPEQM AKYQDECQAH TQAKVAKMLE 480
EEKDKEQRDR ICSDEEEDEE KGGRRIMGPR KKFQWNDEIR ELLCQVVKIK LESQDLERNN 540
KAQAWEDCVK GFLDAEVKPL WPKGWMQART LFKESRRGHG HLTSILAKKK VMAPSKIKVK 600
ESSTKPDKKV SVPSGQIGGP IALPSDHQTG GLSIGASSRE LPSQASGGLA NPPPVNLEDS 660
LDEDLIRNPA SSVEAVSKEL AALNSRAAGN SEFTLPAPSK APAEKVGGVL CTEEKRNFAK 720
PSPSAPPPAS SLQSPLNFLA EQALALGQSS QEKKPESSGY KELSCQAPLN KGLPEVHQSK 780
AKHHSLPRTS HGPQVAVPVP GPQVKVFHAG TQQQKNFTPP SPFANKLQGP KASPTQCHRS 840
LLQLVKTAAK GQGFHPSAPA TSGGLSASSS SSHKTPASSS SALSHPAKPH SVSSAGSSYK 900
NNPFASSISK HGVSSGSSSS GGTPVQSSVS GSLVPGIQPP SVGQATSRPV PSSAGKKMPV 960
SQKLTLVAPP GGPNGDSSGG TQGVAKLLTS PSLKPSAVSS VTSSTSLSKG ASGTVLLAGS 1020
SLMASPYKSS SPKLSGAMSS NSLGIITPVP IPVHVLSFSA DSSAKAGVSK DAIVTGPAPG 1080
SFHHGLGHSL LAGLHSSPPH AAPLPHAAVP THIPQSLPGA SQLHGKGPAV PRKL 1134 
Gene Ontology
 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
 GO:0005923; C:tight junction; ISS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR014840; HRD.
 IPR026936; Ubinuclein-1.
 IPR026949; Ubinuclein/Yemanuclein.
 IPR026947; UBN_middle_dom. 
Pfam
 PF08729; HRD
 PF14075; UBN_AB 
SMART
  
PROSITE
  
PRINTS