UniProt Accession

 CSN1_RAT; P97834 

Genbank Protein ID

 X87885; BC061746 

Genbank Nucleotide ID

 CAA61139.1; AAH61746.1 

Protein Name

 COP9 signalosome complex subunit 1 

Protein Synonyms/Alias

 SGN1; Signalosome subunit 1; G protein pathway suppressor 1; GPS-1; JAB1-containing signalosome subunit 1; MFH protein 

Gene Name

 Gps1 

Gene Synonyms/Alias

 Cops1; Csn1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
121	TRKKALLKLEKLDTD	acetylation	[1]
124	KALLKLEKLDTDLKN	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction (By similarity). 

Sequence Annotation

 DOMAIN 240 408 PCI.
 MOD_RES 448 448 Phosphoserine (By similarity).
 MOD_RES 454 454 Phosphoserine (By similarity).
 MOD_RES 459 459 Phosphothreonine (By similarity).
 MOD_RES 463 463 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Signalosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 471 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008180; C:signalosome; IEA:UniProtKB-KW. 

Interpro

 IPR019585; 26S_proteasome_reg_su-Rpn7.
 IPR000717; PCI_dom.
 IPR011990; TPR-like_helical.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF01399; PCI
 PF10602; RPN7 

SMART

 SM00088; PINT 

PROSITE

  

PRINTS