CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018300
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chromosome transmission fidelity protein 18 homolog 
Protein Synonyms/Alias
 hCTF18; CHL12 
Gene Name
 CHTF18 
Gene Synonyms/Alias
 C16orf41; CTF18 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
256VSLASLKKQVDGERRubiquitination[1]
272RLLQEAQKLSDTLHSubiquitination[1]
396PSQRPKQKVALLCGPubiquitination[1]
483LLSILNRKGPQEVGPubiquitination[1]
572VLAALCEKTDNDIRAubiquitination[1]
869KPLTYQTKQLIAREIubiquitination[1]
880AREIEVEKMRRAEASubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18- RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH. 
Sequence Annotation
 NP_BIND 374 381 ATP (Potential).
 MOD_RES 64 64 Phosphoserine.
 MOD_RES 225 225 Phosphoserine.
 MOD_RES 871 871 Phosphoserine.  
Keyword
 Alternative splicing; ATP-binding; Cell cycle; Complete proteome; DNA replication; DNA-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 975 AA 
Protein Sequence
MEDYEQELCG VEDDFHNQFA AELEVLAELE GASTPSPSGV PLFTAGRPPR TFEEALARGD 60
AASSPAPAAS VGSSQGGARK RQVDADLQPA GSLPHGRLAA LPQGLRSGRE AEEASGSLHV 120
SPPAPRIKRP RLQVVKRLNF RSEEMEEPPP PDSSPTDITP PPSPEDLAEL WGHGVSEAAA 180
DVGLTRASPA ARNPVLRRPP ILEDYVHVTS TEGVRAYLVL RADPMAPGVQ GSLLHVPWRG 240
GGQLDLLGVS LASLKKQVDG ERRERLLQEA QKLSDTLHSL RSGEEEAAQP LGAPEEEPTD 300
GQDASSHCLW VDEFAPRHYT ELLSDDFTNR CLLKWLKLWD LVVFGHERPS RKPRPSVEPA 360
RVSKEATAPG KWKSHEQVLE EMLEAGLDPS QRPKQKVALL CGPPGLGKTT LAHVIARHAG 420
YSVVEMNASD DRSPEVFRTR IEAATQMESV LGAGGKPNCL VIDEIDGAPV AAINVLLSIL 480
NRKGPQEVGP QGPAVPSGGG RRRRAEGGLL MRPIICICND QFAPSLRQLK QQAFLLHFPP 540
TLPSRLVQRL QEVSLRQGMR ADPGVLAALC EKTDNDIRAC INTLQFLYSR GQRELSVRDV 600
QATRVGLKDQ RRGLFSVWQE VFQLPRAQRR RVGQDPALPA DTLLLGDGDA GSLTSASQRF 660
YRVLHAAASA GEHEKVVQGL FDNFLRLRLR DSSLGAVCVA LDWLAFDDLL AGAAHHSQSF 720
QLLRYPPFLP VAFHVLFASS HTPRITFPSS QQEAQNRMSQ MRNLIQTLVS GIAPATRSRA 780
TPQALLLDAL CLLLDILAPK LRPVSTQLYS TREKQQLASL VGTMLAYSLT YRQERTPDGQ 840
YIYRLEPNVE ELCRFPELPA RKPLTYQTKQ LIAREIEVEK MRRAEASARV ENSPQVDGSP 900
PGLEGLLGGI GEKGVHRPAP RNHEQRLEHI MRRAAREEQP EKDFFGRVVV RSTAVPSAGD 960
TAPEQDSVER RMGTAVGRSE VWFRFNEGVS NAVRRSLYIR DLL 1003 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0006260; P:DNA replication; IEA:UniProtKB-KW. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00004; AAA 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS