| Tag | Content |
|---|
| CPLM ID | CPLM-023487 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | A-kinase anchor protein 12 |
Protein Synonyms/Alias | AKAP-12; Germ cell lineage protein gercelin; Src-suppressed C kinase substrate; SSeCKS |
Gene Name | Akap12 |
Gene Synonyms/Alias | Gag12; Ssecks |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 159 | VGFKKVFKFVGFKFT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC) (By similarity). |
Sequence Annotation | DOMAIN 590 620 AKAP 1.
DOMAIN 737 767 AKAP 2.
DOMAIN 778 808 AKAP 3.
REGION 253 543 Involved in PKC-binding (By similarity).
REGION 1501 1514 RII-binding (By similarity).
MOD_RES 18 18 Phosphoserine.
MOD_RES 22 22 Phosphoserine.
MOD_RES 350 350 Phosphoserine (By similarity).
MOD_RES 353 353 Phosphotyrosine.
MOD_RES 467 467 Phosphoserine.
MOD_RES 489 489 Phosphoserine (By similarity).
MOD_RES 543 543 Phosphoserine.
MOD_RES 584 584 Phosphoserine.
MOD_RES 598 598 Phosphoserine.
MOD_RES 613 613 Phosphoserine.
MOD_RES 615 615 Phosphoserine.
MOD_RES 631 631 Phosphoserine.
MOD_RES 632 632 Phosphothreonine.
MOD_RES 634 634 Phosphoserine.
MOD_RES 682 682 Phosphoserine.
MOD_RES 683 683 Phosphoserine.
MOD_RES 684 684 Phosphoserine.
MOD_RES 1292 1292 Phosphoserine (By similarity).
MOD_RES 1355 1355 Phosphoserine (By similarity).
MOD_RES 1546 1546 Phosphoserine (By similarity).
LIPID 2 2 N-myristoyl glycine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Lipoprotein; Myristate; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1684 AA |
Protein Sequence | MGAGSSTEQR SPEQPAESDT PSELELSGHG PAAEASGAAG DPADADPATK LPQKNGQLSA 60
VNGVAEQEDV HVQEESQDGQ EEEVTVEDVG QRESEDVKEK DRAKEMAASS TVVEDITKDE 120
QEETPEIIEQ IPASESNVEE MAQAAESQAN DVGFKKVFKF VGFKFTVKKD KNEKSDTVQL 180
LTVKKDEGEG AEASVGAGDH QEPGVETVGE SASKESELKQ STEKQEGTLK QAQSSTEIPL 240
QAESGQGTEE EAAKDGEENR EKEPTKPLES PTSPVSNETT SSFKKFFTHG WAGWRKKTSF 300
KKPKEDDLET SEKRKEQEAE KVDEEEGEKT EPAPAEEQEP AEGTDQARLS ADYEKVELPL 360
EDQVGDLEAL SEKCAPLATE VFDEKTEAHQ EVVAEVHVST VEKMTKGQGG AEVEGDVVVE 420
GSGESLPPEK LAETQEVPQE AEPVEELMKT KEVCVSGGDH TQLTDLSPEE KMLPKHPEGI 480
VSEVEMLSSQ ERIKVQGSPL KKLFSSSGLK KLSGKKQKGK RGGGGGDEEP GEYQHIQTES 540
PESADEQKGE SSASSPEEPE EIACLEKGPS EAPQEAEAEE GATSDGEKKR EGITPWASFK 600
KMVTPKKRVR RPSESDKEEE LDKVKSATLS STESTASGMQ DEVRAVGEEQ RSEEPKRRVD 660
TSVSWEALIC VGSSKKRARK ASSSDDEGGP RTLGGDGHRA EEASKDKEAD ALPASTQEQD 720
QAHGSSSPEP AGSPSEGEGV STWESFKRLV TPRKKSKSKL EERAEDSGAE QLASEIEPSR 780
EESWVSIKKF IPGRRKKRAD GKQEQAAVED SGPGEINEDD PDVPAVVPLS EYDAVEREKL 840
EAQRAQENVE LPQLKGAVYV SEELSKTLVH TVSVAVIDGT RAVTSAEERS PSWISASMTE 900
PLEHAEGVAT PPVGEVTEKD ITAEATPALA QTLPGGKDAH DDIVTSEVDF TSEAVTAAET 960
TEALRAEELT EASGAEETTD MVSAVSQLSD SPDTTEEATP VQEVEGGMLD TEEQERQTQA 1020
VLQAVADKVK EDSQVPATQT LQRAGPKALE KVEEVEEDSE VLATEKEKDV VPEGPVQEAE 1080
TEHLAQGSET VQATPESLEV PEVTEDVDRA TTCQVIKHQQ LMEQAVAPES SETLTDSETN 1140
GSTPLADSDT PNGTQQDETV DSQDSNAIAA VKQSQVTEEE AAAAQTEGPS TPSSFPAQEE 1200
HREKPGRDVL EPTQALAAGA VPILAKAEVG QEGEAGQFDG EKVKDGQCVK ELEVPVHTGP 1260
NSQKTADLTR DSEVMEVARC QETESNEEQS ISPEKREMGT DVEKEETETK TEQASEEHEQ 1320
ETAAPEHEGT HPKPVLTADM PHSERGKALG SLEGSPSLPD QDKADCIEVQ VQSSDTPVTQ 1380
TTEAVKKVEE TVATSEMDES LECAGAQSLP AEKLSETGGY GTLQHGEDTV PQGPESQAES 1440
IPIIVTPAPE SILHSDLQRE VSASQKQRSD EDNKPDAGPD AAGKESAARE KILRAEPEIL 1500
ELESKSNKIV QSVIQTAVDQ FARTETAPET HASDLQNQVP VMQADSQGAQ QMLDKDESDL 1560
QVSPQDGTLS AVAQEGLAVS DSSEGMSKAS EMITTLAVES ASVKESVEKL PLQCKDEKEH 1620
AADGPQHQSL AKAEADASGN LTKESPDTNG PKLTEEGDAL KEEMNKAQTE EDDLQEPKGD 1680
LTES 1684 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:Compara. GO:0030159; F:receptor signaling complex scaffold activity; TAS:MGI. GO:0030819; P:positive regulation of cAMP biosynthetic process; IEA:Compara. GO:0010739; P:positive regulation of protein kinase A signaling cascade; IEA:Compara. GO:0006605; P:protein targeting; IEA:InterPro. GO:0007165; P:signal transduction; TAS:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |