UniProt Accession

 BAG1_HUMAN; Q99933; O75315; Q14414; Q53H32; Q5VZE8; Q5VZE9; Q5VZF0; Q96TG2; Q9Y2V4 

Genbank Protein ID

 Z35491; U46917; AF022224; AF116273; AK222749; AL161445; AL356472; AL161445; AL356472; AL161445; AL356472; AL356472; AL161445; AL356472; AL161445; AL356472; AL161445; CH471071; CH471071; BC001936; BC014774 

Genbank Nucleotide ID

 CAA84624.1; AAD11467.1; AAC34258.1; AAD25045.1; BAD96469.1; CAH72516.1; CAH72516.1; CAH72517.1; CAH72517.1; CAH72518.1; CAH72518.1; CAH72741.1; CAH72741.1; CAH72742.1; CAH72742.1; CAH72743.1; CAH72743.1; EAW58514.1; EAW58515.1; AAH01936.2; AAH14774.2 

Protein Name

 BAG family molecular chaperone regulator 1 

Protein Synonyms/Alias

 BAG-1; Bcl-2-associated athanogene 1 

Gene Name

 BAG1 

Gene Synonyms/Alias

 HAP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
273	LQAEALCKLDRRVKA	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. 

Sequence Annotation

 REPEAT 96 101 1.
 REPEAT 102 107 2.
 REPEAT 108 113 3.
 REPEAT 114 119 4.
 REPEAT 120 125 5.
 REPEAT 126 131 6.
 REPEAT 132 137 7.
 DOMAIN 144 224 Ubiquitin-like.
 DOMAIN 246 326 BAG.
 REGION 96 137 7 X 6 AA tandem repeat of E-E-X(4).
 REGION 172 219 Interaction with HSPA8.
 REGION 216 345 Interaction with PPP1R15A.
 MOD_RES 223 223 Phosphoserine.  

Keyword

 3D-structure; Alternative initiation; Alternative splicing; Apoptosis; Chaperone; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 345 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005057; F:receptor signaling protein activity; TAS:ProtInc.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
 GO:0070389; P:chaperone cofactor-dependent protein refolding; IDA:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc. 

Interpro

 IPR003103; BAG_domain.
 IPR017093; Molecular_chp_reg_BAG_1.
 IPR000626; Ubiquitin.
 IPR019955; Ubiquitin_supergroup. 

Pfam

 PF02179; BAG
 PF00240; ubiquitin 

SMART

 SM00264; BAG
 SM00213; UBQ 

PROSITE

 PS51035; BAG
 PS00299; UBIQUITIN_1
 PS50053; UBIQUITIN_2 

PRINTS