UniProt Accession

 XRP2_MOUSE; Q9EPK2; Q8BLN8; Q8BVQ8; Q8BZP9 

Genbank Protein ID

 AJ303371; AK033954; AK044002; AK050418; AK076907; AK132713; AK162309; BC049698 

Genbank Nucleotide ID

 CAC21499.1; BAC28525.1; BAC31734.1; BAC34245.1; BAC36524.1; BAE21316.1; BAE36846.1; AAH49698.1 

Protein Name

 Protein XRP2 

Protein Synonyms/Alias

  

Gene Name

 Rp2 

Gene Synonyms/Alias

 Rp2h 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
22	EGEEEQPKLYSWDQR	ubiquitination	[1]
265	GFSLVQTKEMSMKTE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. 

Sequence Annotation

 DOMAIN 21 176 C-CAP/cofactor C-like.
 NP_BIND 95 96 GTP (By similarity).
 NP_BIND 112 115 GTP (By similarity).
 LIPID 2 2 N-myristoyl glycine (By similarity).
 LIPID 3 3 S-palmitoyl cysteine (By similarity).  

Keyword

 Alternative splicing; Cell membrane; Cell projection; Cilium; Complete proteome; GTP-binding; GTPase activation; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Palmitate; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 347 AA 

Protein Sequence

Gene Ontology

 GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
 GO:0004550; F:nucleoside diphosphate kinase activity; IEA:InterPro.
 GO:0000902; P:cell morphogenesis; IEA:InterPro.
 GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
 GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0006228; P:UTP biosynthetic process; IEA:InterPro. 

Interpro

 IPR017901; C-CAP_CF_C-like.
 IPR016098; CAP/MinC_C.
 IPR006599; CARP_motif.
 IPR001564; Nucleoside_diP_kinase.
 IPR017332; Protein_XRP2.
 IPR012945; Tubulin-bd_cofactor_C. 

Pfam

 PF00334; NDK
 PF07986; TBCC 

SMART

 SM00673; CARP 

PROSITE

 PS51329; C_CAP_COFACTOR_C 

PRINTS